2-吡啶酮的高对映选择性加氢。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-06-12 DOI:10.1039/d5ob00833f

Lei Xu, Gen-Qiang Chen, Xumu Zhang

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引用次数: 0

摘要

在此，我们报道了一种高效和对映选择性的Ir-f-phamidol催化2-吡啶酮加氢，使手性吡啶取代仲醇具有优异的对映选择性（高达bbbb99 % ee）和显著的催化效率（S/C高达10000）。该反应的底物范围广、效率高、对映选择性高、反应条件温和，并成功地在克量级上证明了手性醇合成的重大进展，并强调了其实用性和工业意义。

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Highly enantioselective hydrogenation of 2-pyridyl ketones enabled by Ir-f-phamidol catalyst.

Herein, we report a highly efficient and enantioselective Ir-f-phamidol catalysed hydrogenation of 2-pyridyl ketones, enabling the synthesis of chiral pyridyl-substituted secondary alcohols with exceptional enantioselectivity (up to >99% ee) and remarkable catalytic efficiency (S/C up to 10 000). The broad substrate scope, high efficiency and enantioselectivity, mild conditions, and successful gram-scale demonstration of this reaction highlight a significant advancement in chiral alcohol synthesis and underscore its practicality and industrial relevance.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.