纳米材料在病毒防治策略中的应用综述

IF 3.9 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
Bioconjugate Chemistry Pub Date : 2025-07-16 Epub Date: 2025-06-12 DOI:10.1021/acs.bioconjchem.5c00170
Gao-Li Xin, Chong Zhang, Jia-Lin Ni, Yong-Kang Li, Yu Sun, Xiu-Xia He
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引用次数: 0

摘要

病毒感染对人类健康构成重大威胁,并对全球经济产生深远影响。传统疫苗和抗病毒药物在处理病毒感染方面存在一些局限性。例如,疫苗的效力在病毒突变后减弱,而抗病毒药物容易产生耐药性。近年来,纳米材料以其独特的物理化学性质和生物相容性在抗病毒研究中备受关注。本文系统综述了纳米材料在抗病毒方面的应用进展。我们全面概述了纳米材料在各种应用中的抗病毒作用,包括作为疫苗载体增强免疫反应,提高病毒检测的敏感性,通过直接抗病毒活性抑制病毒感染,作为药物递送载体增强药物功效,通过表面涂层中断病毒传播,以及帮助研究病毒机制的病毒追踪。讨论了纳米材料在抗病毒研究中的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanomaterial Applications in Prevention and Treatment Strategies of Virus: A Review.

Virus infections pose significant threats to human health and have profound implications for the global economy. Traditional vaccines and antiviral drugs have several limitations in the management of viral infections. For example, the efficacy of vaccines diminishes following viral mutations, while antiviral medications are susceptible to the development of drug resistance. In recent years, nanomaterials have attracted considerable attention in antiviral research due to their physicochemical properties and biocompatibility. This article provides a systematic overview of the advancements in the antiviral application of nanomaterials. We provide a comprehensive overview of the antiviral effects of nanomaterials in various applications, including the enhancement of immune responses as vaccine carriers, improved sensitivity in virus detection, inhibition of viral infection by direct antiviral activity, enhancement of drug efficacy as drug delivery carriers, interruption of virus transmission by surface coating, and virus tracing to assist in the study of viral mechanisms. Challenges of nanomaterials in the antiviral research are also discussed.

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来源期刊
Bioconjugate Chemistry
Bioconjugate Chemistry 生物-化学综合
CiteScore
9.00
自引率
2.10%
发文量
236
审稿时长
1.4 months
期刊介绍: Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.
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