Considerations for Computational Fluid Dynamics Studies of Cleanrooms Exceeding Classical Indoor Air Simulations: A Systematic Review

We provide a systematic review of the literature on computational fluid dynamics (CFD) in the cleanroom sector. The objective is to provide simulation engineers with an overview of studies in the field of cleanroom simulation, as well as to identify the most commonly used simulation parameters. Our findings indicate a persistent preference for the k − ε model for turbulent flow situations, although recent studies suggest a shift toward more sophisticated models, such as the RNG k − ε and SST k − ω. This reflects advancements in the available computational power made in the past years. Our analysis of particle tracking models indicates a clear preference for the Euler–Lagrange method over the Euler–Euler method. Moreover, the analysis of inlet models used indicates that geometrically resolved diffusers are preferred over simplified models. As every simulation study requires proper validation, full-scale experiments are clearly preferred in the reviewed studies. A best practice guide is distilled out of previous studies to provide a meaningful starting point for future CFD studies in the cleanroom sector.