美国中老年人青少年肥胖与代谢综合征的关系

IF 3.9

Experimental gerontology Pub Date : 2025-06-12 DOI:10.1016/j.exger.2025.112806

Gang Cheng , Ying Zhou , Yan Wang, Chunguang Wang, Jianghong Xu

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引用次数: 0

摘要

目的本研究的目的是观察美国中老年成年人中青少年肥胖与代谢综合征（MetS）之间的关系。方法对年龄≥50岁的美国成年人进行回顾性研究。数据来自1999-2018年周期的国家健康和营养检查调查（NHANES）。获得25岁时的身高和体重水平。计算25岁体重指数（BMI）（BMI25）。25岁时的健康体重、超重和肥胖（健康体重25、超重体重25和肥胖体重25）定义为BMI25 18.5 ~ 25kg /m2、25 ~ 30kg /m2和30kg /m2及以上。MetS是根据国家胆固醇教育计划成人治疗小组III报告（ATP III）定义的。结果健康体重25组、超重体重25组和肥胖体重25组的met患病率分别为48.7%、63.5%和71.4%。在控制混杂因素后，超重25组和肥胖25组的met患病率为2.147 (95%CI: 1.892-2.436, P <；0.001)和2.878 (95%CI: 2.304-3.597, P <；0.001)，是健康体重25组的1倍。在进一步调整调查时的BMI后，超重25组和肥胖25组的met患病率分别是健康体重25组的1.193 （95%CI:1.035 ~ 1.375,P = 0.015）和1.222 （95%CI:0.959 ~ 1.557,P = 0.105）倍。结论本研究表明，青少年肥胖与中老年人群met风险增加密切相关。

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The relationship between youth obesity and metabolic syndrome among middle-aged and elderly adults in the United States

Objective

The purpose of this study was to observe the relationship between youth obesity and metabolic syndrome (MetS) among middle-aged and elderly adults in the United States.

Methods

A retrospective study was conducted on United States adults aged ≥50 years. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 cycles. The levels of height and weight at aged 25 years were obtained. Body mass index (BMI) at aged 25 years (BMI₂₅) was calculated. Healthy weight, overweight and obesity at aged 25 years (healthy weight₂₅, overweight₂₅ and obesity₂₅) were defined as BMI₂₅ 18.5 to <25 kg/m², 25 to <30 kg/m² and 30 kg/m² or greater. MetS was defined According to the National Cholesterol Education Program's Adult Treatment Panel III report (ATP III).

Results

The prevalences of MetS were 48.7 %, 63.5 %, and 71.4 % in adults with healthy weight₂₅, overweight₂₅, and obesity₂₅ group. After control for confounding factors, the prevalences of MetS in overweight₂₅ group and obesity₂₅ group were 2.147 (95%CI: 1.892–2.436, P < 0.001) times and 2.878 (95%CI: 2.304–3.597, P < 0.001) times than that in healthy weight₂₅ group. After further adjusted for BMI at the time of survey, the prevalences of MetS in adults with overweight₂₅ group and obesity₂₅ group were 1.193 (95%CI:1.035–1.375，P = 0.015) times and 1.222 (95%CI:0.959–1.557，P = 0.105) times than adults with healthy weight₂₅ group.