[双（三氟乙酰氧基）碘]苯介导的α-氧酮二硫缩醛的区域选择性(sp2) -H硒化反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-06-06 DOI:10.1016/j.tetlet.2025.155685

Anirban Mandal, Sanjay Roy, Sajal Das

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引用次数: 0

摘要

在此，我们报道了由[双（三氟乙酰氧基）碘]-苯（PIFA）介导的α-氧酮二硫缩醛的C(sp2) -H键硒化反应。以92%的收率制备了结构多样的硒醚衍生物库。该反应发生在室温下，不需要任何过渡金属催化剂。并对反应途径进行了深入的研究。在大规模合成中发现该反应同样活跃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

[Bis(trifluoroacetoxy)iodo]benzene mediated regioselectivec(sp2)–H selenylation of α-oxo ketene dithioacetals under ambient conditions

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[Bis(trifluoroacetoxy)iodo]benzene mediated regioselectivec(sp2)–H selenylation of α-oxo ketene dithioacetals under ambient conditions

Herein, we report a regioselective C(sp²)–H bond selenylation of α-oxo ketene dithioacetals mediated by [Bis(trifluoroacetoxy)iodo]-benzene (PIFA) using readily available organodiselenides. A library of structurally diverse selenoether derivatives is prepared with a high yield of 92 %. This reaction occurs at ambient temperature and does not require any transition metal catalyst. An in-depth study has also been done to enlighten the reaction pathway. The reaction is found to be equally active in up-scale synthesis.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.