初级保健患者皮肤癌基因检测后家庭沟通的前瞻性变化

PEC innovation Pub Date : 2025-06-07 DOI:10.1016/j.pecinn.2025.100409

Caroline Salafia , Smita Banerjee , Jada G. Hamilton , Elizabeth Schofield , Yuelin Li , David B. Buller , Keith Hunley , Andrew L. Sussman , Dolores D. Guest , Kimberly A. Kaphingst , Marianne Berwick , Jennifer L. Hay

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引用次数: 0

摘要

目的：考虑到家庭沟通促进癌症风险意识的承诺，我们研究了皮肤癌基因检测的提议如何促进家庭癌症沟通。方法将新墨西哥州的初级保健患者（N = 415, 45%为西班牙裔）随机分为邀请组和常规组进行黑素皮质素-1受体（MC1R）基因检测。我们评估了家庭沟通（频率、沟通目标和话题）是否根据参与者是否被随机分配到常规护理、拒绝基因检测、接受检测并接受平均或更高风险的反馈而有所不同。结果干预暴露对家庭沟通频率的影响无显著性差异。那些接受测试并得到高风险反馈的人与特定目标（如父亲）的沟通水平最高。一些交流话题，比如参与者患皮肤癌的风险，接受测试的参与者（包括平均风险和高风险的反馈）比接受常规护理的参与者讨论得更多。结论：研究结果强调，提供皮肤癌基因检测可能会促进家庭沟通，例如围绕个人皮肤癌风险的讨论。创新：这项研究在接受皮肤癌基因检测后，调查了家庭交流的各种因素。

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Prospective changes in primary care patients' family communication after skin cancer genetic test offer

Objective

Given the promise of family communication to prompt cancer risk awareness, we examined how an offer for skin cancer genetic testing may prompt family cancer communication.

Methods

Primary care patients (N = 415, 45 % Hispanic) in New Mexico were randomized to a melanocortin-1 receptor (MC1R) genetic test invitation or usual care. We assessed whether family communication (frequency, targets of communication, and topics) differed based on whether participants were randomized to usual care, refused genetic testing, were tested and received either average- or higher-risk feedback.

Results

Findings showed no significant differences in frequency of family communication based on intervention exposure. Those who were tested and received higher-risk feedback displayed the highest levels of communication with certain targets, such as fathers. Some communication topics, such as the participant's risk of skin cancer, were discussed more by participants who were tested (both average- and higher-risk feedback) than those in usual care.

Conclusion

Findings highlight that an offer for skin cancer genetic testing may prompt aspects of family communication, such as discussion surrounding personal skin cancer risk.