硝酸钙时间对介孔SiO2-CaO纳米颗粒结构和结构特性的影响

IF 2.9 Q1 MATERIALS SCIENCE, CERAMICS

Open Ceramics Pub Date : 2025-06-12 DOI:10.1016/j.oceram.2025.100807

Onat Başak , Fatih Kurtuldu , Jan Ilavský , Martina Vitázková , Ana M. Beltrán , Francisco Muñoz , Yolanda Castro , Martin Michálek , Maria Chromčíková

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引用次数: 0

摘要

介孔生物活性玻璃纳米颗粒（MBGNPs）由于其高孔容和比表面积，是一种很有前途的药物递送材料。本研究考察了硝酸钙添加时间对微乳辅助溶胶-凝胶法制备MBGNPs结构和结构特性的影响。延迟添加硝酸钙使CaO掺入率从14.2%降低到9.5 mol%，使粒径从178±51 nm增加到256±30 nm。通过BET和USAXS/SAXS测量可以观察到，比表面积值随着硝酸钙的延迟添加而增加。QSin单位的比例略有变化，但在成骨样细胞中未观察到细胞毒性。这些发现为优化生物医学应用的MBGNP合成提供了有价值的见解。

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Influence of calcium nitrate timing on the structural and textural characteristics of mesoporous SiO2-CaO nanoparticles

Mesoporous bioactive glass nanoparticles (MBGNPs) are promising materials for drug delivery due to their high pore volume and specific surface area. This study investigates how the timing of calcium nitrate addition affects the structural and textural characteristics of MBGNPs synthesized via a microemulsion-assisted sol-gel method. Delayed calcium nitrate addition reduced CaO incorporation from 14.2 to 9.5 mol% and increased particle size from 178 ± 51 nm to 256 ± 30 nm. The specific surface area values increased with the delayed addition of calcium nitrate, as observed through BET and USAXS/SAXS measurements. The proportion of Q_Siⁿ units slightly changed, but no cytotoxicity was observed in osteoblast-like cells. These findings provide valuable insights into optimizing MBGNP synthesis for biomedical applications.

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