疾病管理中的自噬：探索天然产物作为靶向治疗的潜力

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-06-09 DOI:10.1016/j.prp.2025.156077

Laila A. Eissa , Amani M. Marawan , Mohamed E. Marawan , Shimaa A. Abass

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引用次数: 0

摘要

自噬是一个重要的细胞过程，通过溶酶体降解和循环细胞内成分，在维持细胞稳态中起着关键作用。这一机制的改变与许多疾病的发生和进展有关，包括癌症、神经退行性疾病、心血管疾病、微生物和病毒感染。最近的研究已经确定了一些影响自噬相关基因的突变，并阐明了特定底物的缺陷降解如何促进疾病机制。天然产物因其通过几个分子靶点调节自噬的能力而受到关注。因此，我们强调了自噬在疾病发病机制中的复杂作用。我们还说明了天然产物如何通过针对不同病理背景下的自噬提供治疗价值。

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Autophagy in disease management: Exploring the potential of natural products as targeted therapies

Autophagy is a vital cellular process that degrades and recycles intracellular components via lysosomes, playing a key role in maintaining cellular homeostasis. Alteration of this mechanism has been implicated in the occurrence and progression of numerous diseases, including cancer, neurodegenerative disorders, cardiovascular conditions, and microbial and viral infections. Recent studies have identified several mutations affecting autophagy-related genes and elucidated how defective degradation of specific substrates contributes to disease mechanisms. Natural products are gaining attention for their ability to modulate autophagy through several molecular targets. Herin, we highlight the complicated role of autophagy in disease pathogenesis. We also illustrate how natural products may offer therapeutic value by targeting autophagy in different pathological contexts.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.