两种未描述的飞燕草（Delphinium naviculare var. lasiocarpum） c18 -二萜生物碱

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-06-12 DOI:10.1016/j.phytol.2025.103000

Wen-juan Xue , Nurfida Ablajan , Bo Zhao , Yu-qing Yang , Xue-ying Lu , Jiang-yu Zhao , Shamansur Sagdullaev , Haji Akber Aisa

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引用次数: 0

摘要

从飞禽飞草（Delphinium naviculare var. lasiocarpum）的地上部分分离到两个c18 -二萜生物碱naviculamine A(1)和naviculamine B(2)，以及一个已知的c19 -二萜生物碱septentriodine(3)。化合物1是一种前所未有的骨架c18 -二萜生物碱，在C-7和C-17之间化学键断裂。化合物2是一种从自然界中发现的较为罕见的硝基c18 -二萜生物碱。基于光谱分析，包括HR-ESI-MS、1D和2D核磁共振光谱数据和ECD，确定了它们的化学结构。并评价了这些二萜生物碱对hERG和CaV3.1通道的抑制作用。

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Two undescribed C18-diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang

Two C₁₈-diterpenoid alkaloids naviculamine A (1) and naviculamine B (2), together with one known C₁₉-diterpenoid alkaloids septentriodine (3) were isolated from the aerial part of Delphinium naviculare var. lasiocarpum. Compound 1 was an unprecedented skeleton C₁₈-diterpenoid alkaloid with chemical bond breakage between C-7 and C-17. Compound 2 was a relatively rare nitrone C₁₈-diterpenoid alkaloid discovered from natural. Their chemical structures were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR spectroscopic data and ECD. The inhibitory effects of these diterpenoid alkaloids on hERG and CaV3.1 channels were also evaluated.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.