Xiaolei Wang , Jingguo Zhang , Jing Feng , Shurui Han , Chan Huang , Zhiyun Kong , Huicai Wang
{"title":"cf3功能化聚酰胺层提高聚酰亚胺基有机溶剂纳滤膜药物分离的溶剂渗透性","authors":"Xiaolei Wang , Jingguo Zhang , Jing Feng , Shurui Han , Chan Huang , Zhiyun Kong , Huicai Wang","doi":"10.1016/j.jwpe.2025.108139","DOIUrl":null,"url":null,"abstract":"<div><div>An organic solvent nanofiltration (OSN) membrane was fabricated through interfacial polymerization (IP) to form a selective layer containing hydrophilic amide (–CONH–) and hydrophobic trifluoromethyl (–CF<sub>3</sub>) groups on a polyimide (PI) substrate. Piperazine (PIP) and 5-trifluoromethyl-1,3-phenylenediamine (TFMPD) were employed as aqueous phase monomers, reacting with trimesoyl chloride (TMC) in the organic phase. The effects of TFMPD incorporation on the chemical structure, morphology, surface properties, separation performance, and stability of the membranes were systematically investigated. The results revealed that the competitive reaction between TFMPD and PIP led to a thinner selective layer with reduced cross-linking degree, thereby enhancing solvent permeance while maintaining consistent pharmaceutical rejection. Specifically, the introduction of –CF<sub>3</sub> groups improved non-polar solvent transport, achieving a 3.2-fold increase in n-hexane permeance. After 91 days of immersion in <em>N</em>, <em>N</em>-dimethylformamide (DMF), the membrane retained ~94 % rifampicin (RFP) rejection and maintained an ethanol/water permeance of ~4.5 L·m<sup>−2</sup>·h<sup>−1</sup>·bar<sup>−1</sup>. This work demonstrates a rational design strategy for developing solvent-resistant OSN membranes with balanced permeability-selectivity-stability for pharmaceutical separation in organic solvents.</div></div>","PeriodicalId":17528,"journal":{"name":"Journal of water process engineering","volume":"76 ","pages":"Article 108139"},"PeriodicalIF":6.7000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CF3-functionalized polyamide layers enhancing solvent permeability of polyimide-based organic solvent nanofiltration membranes for pharmaceutical separation\",\"authors\":\"Xiaolei Wang , Jingguo Zhang , Jing Feng , Shurui Han , Chan Huang , Zhiyun Kong , Huicai Wang\",\"doi\":\"10.1016/j.jwpe.2025.108139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>An organic solvent nanofiltration (OSN) membrane was fabricated through interfacial polymerization (IP) to form a selective layer containing hydrophilic amide (–CONH–) and hydrophobic trifluoromethyl (–CF<sub>3</sub>) groups on a polyimide (PI) substrate. Piperazine (PIP) and 5-trifluoromethyl-1,3-phenylenediamine (TFMPD) were employed as aqueous phase monomers, reacting with trimesoyl chloride (TMC) in the organic phase. The effects of TFMPD incorporation on the chemical structure, morphology, surface properties, separation performance, and stability of the membranes were systematically investigated. The results revealed that the competitive reaction between TFMPD and PIP led to a thinner selective layer with reduced cross-linking degree, thereby enhancing solvent permeance while maintaining consistent pharmaceutical rejection. Specifically, the introduction of –CF<sub>3</sub> groups improved non-polar solvent transport, achieving a 3.2-fold increase in n-hexane permeance. After 91 days of immersion in <em>N</em>, <em>N</em>-dimethylformamide (DMF), the membrane retained ~94 % rifampicin (RFP) rejection and maintained an ethanol/water permeance of ~4.5 L·m<sup>−2</sup>·h<sup>−1</sup>·bar<sup>−1</sup>. This work demonstrates a rational design strategy for developing solvent-resistant OSN membranes with balanced permeability-selectivity-stability for pharmaceutical separation in organic solvents.</div></div>\",\"PeriodicalId\":17528,\"journal\":{\"name\":\"Journal of water process engineering\",\"volume\":\"76 \",\"pages\":\"Article 108139\"},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2025-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of water process engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214714425012115\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of water process engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214714425012115","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
CF3-functionalized polyamide layers enhancing solvent permeability of polyimide-based organic solvent nanofiltration membranes for pharmaceutical separation
An organic solvent nanofiltration (OSN) membrane was fabricated through interfacial polymerization (IP) to form a selective layer containing hydrophilic amide (–CONH–) and hydrophobic trifluoromethyl (–CF3) groups on a polyimide (PI) substrate. Piperazine (PIP) and 5-trifluoromethyl-1,3-phenylenediamine (TFMPD) were employed as aqueous phase monomers, reacting with trimesoyl chloride (TMC) in the organic phase. The effects of TFMPD incorporation on the chemical structure, morphology, surface properties, separation performance, and stability of the membranes were systematically investigated. The results revealed that the competitive reaction between TFMPD and PIP led to a thinner selective layer with reduced cross-linking degree, thereby enhancing solvent permeance while maintaining consistent pharmaceutical rejection. Specifically, the introduction of –CF3 groups improved non-polar solvent transport, achieving a 3.2-fold increase in n-hexane permeance. After 91 days of immersion in N, N-dimethylformamide (DMF), the membrane retained ~94 % rifampicin (RFP) rejection and maintained an ethanol/water permeance of ~4.5 L·m−2·h−1·bar−1. This work demonstrates a rational design strategy for developing solvent-resistant OSN membranes with balanced permeability-selectivity-stability for pharmaceutical separation in organic solvents.
期刊介绍:
The Journal of Water Process Engineering aims to publish refereed, high-quality research papers with significant novelty and impact in all areas of the engineering of water and wastewater processing . Papers on advanced and novel treatment processes and technologies are particularly welcome. The Journal considers papers in areas such as nanotechnology and biotechnology applications in water, novel oxidation and separation processes, membrane processes (except those for desalination) , catalytic processes for the removal of water contaminants, sustainable processes, water reuse and recycling, water use and wastewater minimization, integrated/hybrid technology, process modeling of water treatment and novel treatment processes. Submissions on the subject of adsorbents, including standard measurements of adsorption kinetics and equilibrium will only be considered if there is a genuine case for novelty and contribution, for example highly novel, sustainable adsorbents and their use: papers on activated carbon-type materials derived from natural matter, or surfactant-modified clays and related minerals, would not fulfil this criterion. The Journal particularly welcomes contributions involving environmentally, economically and socially sustainable technology for water treatment, including those which are energy-efficient, with minimal or no chemical consumption, and capable of water recycling and reuse that minimizes the direct disposal of wastewater to the aquatic environment. Papers that describe novel ideas for solving issues related to water quality and availability are also welcome, as are those that show the transfer of techniques from other disciplines. The Journal will consider papers dealing with processes for various water matrices including drinking water (except desalination), domestic, urban and industrial wastewaters, in addition to their residues. It is expected that the journal will be of particular relevance to chemical and process engineers working in the field. The Journal welcomes Full Text papers, Short Communications, State-of-the-Art Reviews and Letters to Editors and Case Studies