通过[4 + 1 + 1]和[3 + 1 + 1]环化反应合成α-羰基和四氢吡咯[2,3-b]吲哚的温度依赖性、可切换性

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-30 DOI:10.1021/acs.joc.5c0068310.1021/acs.joc.5c00683

Siyang Xing*, Lvrong Jin, Fangfang Jing, Xiqing Wang, Jingyu Pang and Bolin Zhu*,

引用次数: 0

摘要

研究了一种由3-乙烯基多、磺酰叠氮化物和α-溴酮组成的可切换的单锅三组分环化反应，用于合成α-碳卡啉和四氢吡咯[2,3-b]吲哚。该策略的优点是产品选择性好，官能团耐受性好，产品功能化程度高，条件温和。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Temperature-Dependent, Switchable Synthesis of α-Carbolines and Tetrahydropyrrolo[2,3-b]indoles via Formal [4 + 1 + 1] and [3 + 1 + 1] Cyclizations

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Temperature-Dependent, Switchable Synthesis of α-Carbolines and Tetrahydropyrrolo[2,3-b]indoles via Formal [4 + 1 + 1] and [3 + 1 + 1] Cyclizations

A switchable one-pot, three-component cyclization of 3-vinylindoles, sulfonyl azides, and α-bromoketones has been developed for the synthesis of α-carbolines and tetrahydropyrrolo[2,3-b]indoles. The advantages of this strategy include excellent product selectivity, good functional group tolerance, highly functionalized products, and mild conditions.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.