Kurella Mounika, Dasari Srinivas and Gedu Satyanarayana*,
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The meta-Selective C–H Functionalization of Phenol Derivatives Using a Nitrile-Based Directing Group
While ortho-C–H activation has been well explored, meta-C–H functionalization of phenols remains challenging due to regioselectivity constraints. Here, we introduce a site-selective meta-C–H olefination strategy using an aliphatic nitrile template under mild room-temperature conditions. This approach leverages nitrile–metal interactions to enable efficient C–H activation, overcoming the harsh conditions required in traditional methods. With a broad substrate scope and high efficiency, this method has been successfully applied to drug-like and natural product derivatives, delivering high yields and selectivities.
期刊介绍:
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.