解开孟德尔最后的谜团：豌豆遗传学的基因组重述

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-06-12 DOI:10.1016/j.cell.2025.04.029

Murukarthick Jayakodi, Preethi Purushotham, Nils Stein

{"title":"解开孟德尔最后的谜团：豌豆遗传学的基因组重述","authors":"Murukarthick Jayakodi, Preethi Purushotham, Nils Stein","doi":"10.1016/j.cell.2025.04.029","DOIUrl":null,"url":null,"abstract":"Using modern genomic tools, Feng et al. revisited Mendel’s seven pea traits in a recent <em>Nature</em> study, uncovering the molecular genetic basis of all of them, including the three unresolved ones: pod color, pod shape, and flower position. Their work highlights the level of complexity provided by structural variation that could impact genes and their regulatory regions and thus influence the expression of plant traits. The authors demonstrate how revisiting foundational experiments with contemporary tools can manifest novel biological insights and also guide future crop improvement.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"19 1","pages":""},"PeriodicalIF":42.5000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics\",\"authors\":\"Murukarthick Jayakodi, Preethi Purushotham, Nils Stein\",\"doi\":\"10.1016/j.cell.2025.04.029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Using modern genomic tools, Feng et al. revisited Mendel’s seven pea traits in a recent <em>Nature</em> study, uncovering the molecular genetic basis of all of them, including the three unresolved ones: pod color, pod shape, and flower position. Their work highlights the level of complexity provided by structural variation that could impact genes and their regulatory regions and thus influence the expression of plant traits. The authors demonstrate how revisiting foundational experiments with contemporary tools can manifest novel biological insights and also guide future crop improvement.\",\"PeriodicalId\":9656,\"journal\":{\"name\":\"Cell\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":42.5000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cell.2025.04.029\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cell.2025.04.029","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

利用现代基因组工具，Feng等人在最近的Nature研究中重新审视了孟德尔的七个豌豆性状，揭示了所有这些性状的分子遗传基础，包括三个未解决的性状：豆荚颜色、豆荚形状和花的位置。他们的工作强调了结构变异提供的复杂性水平，这些变异可能影响基因及其调控区域，从而影响植物性状的表达。作者展示了如何用现代工具重新审视基础实验，从而体现出新的生物学见解，并指导未来的作物改良。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics

Using modern genomic tools, Feng et al. revisited Mendel’s seven pea traits in a recent Nature study, uncovering the molecular genetic basis of all of them, including the three unresolved ones: pod color, pod shape, and flower position. Their work highlights the level of complexity provided by structural variation that could impact genes and their regulatory regions and thus influence the expression of plant traits. The authors demonstrate how revisiting foundational experiments with contemporary tools can manifest novel biological insights and also guide future crop improvement.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.