G. Renau , D. Abelló , F. Sabench , J. Doménech , A. Sánchez
{"title":"c反应蛋白作为复杂急性胆囊炎的预测因子：一项队列研究。","authors":"G. Renau , D. Abelló , F. Sabench , J. Doménech , A. Sánchez","doi":"10.1016/j.rgmxen.2025.02.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).</div></div><div><h3>Material and methods</h3><div>A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.</div></div><div><h3>Results</h3><div>The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (<em>p</em> < 0.001; OR 11.8), AUC of 0.88 (<em>p =</em> 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (<em>p</em> < 0.031; OR 5), AUC of 0.81(<em>p</em> = 0.037), and cutoff point of 11.09 x 10<sup>9</sup>/l (78% sensitivity, 70% specificity).</div></div><div><h3>Conclusions</h3><div>CRP may have a higher predictive capacity for LCAC than leukocytosis.</div></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 2","pages":"Pages 330-333"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"C-reactive protein as a predictor of complicated acute cholecystitis: A cohort study\",\"authors\":\"G. Renau , D. Abelló , F. Sabench , J. Doménech , A. Sánchez\",\"doi\":\"10.1016/j.rgmxen.2025.02.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).</div></div><div><h3>Material and methods</h3><div>A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.</div></div><div><h3>Results</h3><div>The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (<em>p</em> < 0.001; OR 11.8), AUC of 0.88 (<em>p =</em> 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (<em>p</em> < 0.031; OR 5), AUC of 0.81(<em>p</em> = 0.037), and cutoff point of 11.09 x 10<sup>9</sup>/l (78% sensitivity, 70% specificity).</div></div><div><h3>Conclusions</h3><div>CRP may have a higher predictive capacity for LCAC than leukocytosis.</div></div>\",\"PeriodicalId\":74705,\"journal\":{\"name\":\"Revista de gastroenterologia de Mexico (English)\",\"volume\":\"90 2\",\"pages\":\"Pages 330-333\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista de gastroenterologia de Mexico (English)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2255534X25000702\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de gastroenterologia de Mexico (English)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2255534X25000702","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
C-reactive protein as a predictor of complicated acute cholecystitis: A cohort study
Introduction
The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).
Material and methods
A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.
Results
The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (p < 0.001; OR 11.8), AUC of 0.88 (p = 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (p < 0.031; OR 5), AUC of 0.81(p = 0.037), and cutoff point of 11.09 x 109/l (78% sensitivity, 70% specificity).
Conclusions
CRP may have a higher predictive capacity for LCAC than leukocytosis.
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