非自杀性自伤和自杀企图的药物幼稚抑郁青少年的结构网络沟通差异。

IF 3.4 4区 医学 Q1 PSYCHIATRY
Shuai Wang, Jiao-Long Qin, Lian-Lian Yang, Ying-Ying Ji, Hai-Xia Huang, Xiao-Shan Gao, Zi-Mo Zhou, Zhen-Ru Guo, Ye Wu, Lin Tian, Huang-Jing Ni, Zhen-He Zhou
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引用次数: 0

摘要

背景:抑郁症、非自杀性自伤(NSSI)和自杀企图(SA)经常在青春期同时发生,并与长期不良健康结果相关。不幸的是,青少年抑郁症中自伤和SA的神经机制尚不清楚,但可能与大脑区域的结构异常有关。目的:探讨抑郁症青少年大尺度脑网络的结构网络通讯。方法:构建五种不同的网络沟通模型,在全脑水平上评估青少年抑郁症的结构网络效率。扩散磁共振成像数据来自32名健康对照和85名抑郁青少年,其中无SA或自伤的抑郁青少年17名(重度抑郁障碍组),有自伤但无SA的抑郁青少年27名(自伤组),有SA和自伤的抑郁青少年41名(自伤+自伤组)。结果:在四组中观察到结构网络通信的显著差异,涉及空间广泛的大脑区域,特别是包括皮质-皮质连接(例如,扣带回后背和右腹侧扣带回后回;基于中央前回和皮质-皮质下回路(如伏隔核-额叶回路)的连接。此外,我们还研究了沟通效率低下是否与抑郁青少年的临床症状有关。我们观察到网络沟通效率与抑郁青少年自伤和SA的临床量表得分之间存在显著相关性。结论:本研究为患有自伤和SA的抑郁青少年提供了结构网络沟通差异的证据,强调神经解剖沟通效率受损是其症状的潜在因素。这些发现为青少年抑郁症中自伤和SA合并症的病理生理机制提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural network communication differences in drug-naive depressed adolescents with non-suicidal self-injury and suicide attempts.

Background: Depression, non-suicidal self-injury (NSSI), and suicide attempts (SA) often co-occur during adolescence and are associated with long-term adverse health outcomes. Unfortunately, neural mechanisms underlying self-injury and SA are poorly understood in depressed adolescents but likely relate to the structural abnormalities in brain regions.

Aim: To investigate structural network communication within large-scale brain networks in adolescents with depression.

Methods: We constructed five distinct network communication models to evaluate structural network efficiency at the whole-brain level in adolescents with depression. Diffusion magnetic resonance imaging data were acquired from 32 healthy controls and 85 depressed adolescents, including 17 depressed adolescents without SA or NSSI (major depressive disorder group), 27 depressed adolescents with NSSI but no SA (NSSI group), and 41 depressed adolescents with SA and NSSI (NSSI + SA group).

Results: Significant differences in structural network communication were observed across the four groups, involving spatially widespread brain regions, particularly encompassing cortico-cortical connections (e.g., dorsal posterior cingulate gyrus and the right ventral posterior cingulate gyrus; connections based on precentral gyrus) and cortico-subcortical circuits (e.g., the nucleus accumbens-frontal circuit). In addition, we examined whether compromised communication efficiency was linked to clinical symptoms in the depressed adolescents. We observed significant correlations between network communication efficiencies and clinical scale scores derived from depressed adolescents with NSSI and SA.

Conclusion: This study provides evidence of structural network communication differences in depressed adolescents with NSSI and SA, highlighting impaired neuroanatomical communication efficiency as a potential contributor to their symptoms. These findings offer new insights into the pathophysiological mechanisms underlying the comorbidity of NSSI and SA in adolescent depression.

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来源期刊
自引率
6.50%
发文量
110
期刊介绍: The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.
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