血清25羟基维生素D与儿童血红蛋白和其他贫血参数呈正相关：一项横断面研究。

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-06-10 DOI:10.1186/s12986-025-00949-6

Hongli Dong, Xiaojing Xu, Liang Gao, Yufei Ni

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引用次数: 0

摘要

背景：以往的体外研究表明25羟基维生素D [25(OH)D]可能参与贫血参数的调节，但在儿童中缺乏流行病学证据。我们探讨了25(OH)D与儿童血红蛋白（Hb）和其他贫血参数（平均红细胞体积[MCV]、平均红细胞血红蛋白浓度[MCHC]和血清铁蛋白[SF]）的关系。方法：对中国南通10227名儿童（平均年龄14.6个月）进行横断面研究。测定血清25(OH)D、MCV、MCHC和SF浓度。结果：调整潜在协变量后，血清25(OH)D与贫血参数呈正相关(四分位数[Q] 4 vs. Q1: Hb为127.304 vs. 78.982 g/L；MCV为83.957 vs 66.264 fL；334.551 g/L vs. 208.368 g/L；SF: 34.277 vs. 32.807 ng/mL)。在按性别进行的分层分析中也显示出类似的结果。在多变量分析中，总体人群中较高的25(OH)D与较低的贫血风险相关（ORQ4 vs. Q1: 0.06, 95% CIQ4 vs. Q1: 0.05, 0.07）。此外，hsCRP介导了“25(OH) d -贫血参数（Hb、MCV和MCHC）”和“25(OH) d -贫血”的关联。结论：总的来说，我们的研究结果进一步支持了25(OH)D在中国儿童中的抗贫血作用。需要进一步的研究在不同的人群和实验环境中重复这些结果。

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Serum 25 hydroxyvitamin D was positively associated with hemoglobin and other anemia parameters in children: a cross-sectional study.

Background: Previous in vitro studies indicated that 25 hydroxyvitamin D [25(OH)D] might contribute to the modulation of anemia parameters while epidemiological evidences were scarce in children. We explored the associations of 25(OH)D with hemoglobin (Hb) and other anemia parameters (mean corpuscular volume [MCV], mean corpuscular hemoglobin concentration [MCHC], and serum ferritin [SF]) in children.

Methods: A cross-sectional study involving 10,227children (mean age 14.6 months) in Nantong, China, was carried out. Serum 25(OH)D, MCV, MCHC, and SF concentrations were measured.

Results: After adjustment for the potential covariates, serum 25(OH)D was positively associated with anemia parameters (quartile [Q] 4 vs. Q1: 127.304 vs. 78.982 g/L for Hb; 83.957 vs. 66.264 fL for MCV; 334.551 vs. 208.368 g/L for MCHC; 34.277 vs. 32.807 ng/mL for SF). Similar results were shown in the stratified analyses by gender. Consistently, a higher 25(OH)D was found to be related with a lower risk of anemia (OR_{Q4 vs. Q1}: 0.06, 95% CI_{Q4 vs. Q1}: 0.05, 0.07) in multi-variable analysis among total populations. Additionally, the "25(OH)D-anemia parameters (Hb, MCV, and MCHC)" and "25(OH)D-anemia" associations were mediated by hsCRP.

Conclusions: In general, our findings provided further support for the anti-anemia effects of 25(OH)D in Chinese children. Further research is warranted to replicate these results in different populations and in experimental settings.

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.