粘心铕中abie烷二萜和taraxer烷型三萜。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-06-10 DOI:10.1080/14786419.2025.2514733

Tong Xue, Chun Gao, Hao Chen, Muhi Eldeen Hussien Ibrahim, Hongzheng Fu, Jianbin Wang

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引用次数: 0

摘要

从粘豆豆（Teucrium visidum）全株中分离到两个abietane二萜，分别命名为teuvisamine A(1)和B(2)，以及两个新的taraxerane型三萜，分别命名为teuvisoic acid A(3)和B(4)。通过hresms光谱和NMR光谱分析以及与已发表数据的比较，对其结构进行了鉴定。所有分离物对5种人类癌细胞系（HCT116、H460、HepG2、BGC823和HeLa细胞）的细胞毒活性进行了评估。化合物3对HCT116和H460具有中等的细胞毒活性，IC50值分别为6.2 μM和8.6 μM。

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Abietane diterpenoids and taraxerane-type triterpenes from Teucrium viscidum.

Two abietane diterpenoids, named teuvismine A (1) and B (2), along with two new taraxerane-type triterpenes, named teuvisoic acid A (3) and B (4) were isolated from whole plants of Teucrium viscidum. The structures were elucidated by the analysis of HRESIMS spectroscopy and NMR spectroscopy, as well as the comparison with published data. All isolates were evaluated for their cytotoxic activities against five human cancer cell lines (HCT116, H460, HepG2, BGC823, and HeLa cells). Compound 3 showed moderate cytotoxic activities against HCT116 and H460 with IC₅₀ values of 6.2 and 8.6 μM, respectively.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.