免疫细胞对生殖疾病的因果影响,包括异常精子、多囊卵巢综合征和自然流产:孟德尔随机分析。

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S524949
Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo
{"title":"免疫细胞对生殖疾病的因果影响,包括异常精子、多囊卵巢综合征和自然流产:孟德尔随机分析。","authors":"Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo","doi":"10.2147/JMDH.S524949","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.</p><p><strong>Methods: </strong>Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.</p><p><strong>Results: </strong>For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between <i>CD11c+ CD62L- monocyte%monocyte</i> (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. <i>CD4 on CM CD4+</i> (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of <i>CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes</i> (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.</p><p><strong>Conclusion: </strong>This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3219-3232"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151076/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.\",\"authors\":\"Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo\",\"doi\":\"10.2147/JMDH.S524949\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.</p><p><strong>Methods: </strong>Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.</p><p><strong>Results: </strong>For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between <i>CD11c+ CD62L- monocyte%monocyte</i> (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. <i>CD4 on CM CD4+</i> (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of <i>CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes</i> (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.</p><p><strong>Conclusion: </strong>This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.</p>\",\"PeriodicalId\":16357,\"journal\":{\"name\":\"Journal of Multidisciplinary Healthcare\",\"volume\":\"18 \",\"pages\":\"3219-3232\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151076/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Multidisciplinary Healthcare\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JMDH.S524949\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S524949","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0

摘要

背景:累积的先前研究表明,免疫炎症深刻影响中胚层起源的生殖障碍。然而,人们对免疫因素与生殖系统疾病之间的因果关系知之甚少。方法:采用双样本孟德尔随机化(MR)分析,确定731种免疫性状与生殖健康不良的因果关系,包括异常精子(AS)、多囊卵巢综合征(PCOS)和自然流产(SA)。使用全基因组关联研究(GWAS)数据解密因果关系。进行敏感性分析以评估结果的强度、异质性和水平多效性。结果:对于AS,鉴定出34种因果关系,b细胞组中的BAFF-R、CD20和CD27对AS具有保护作用。CD11c+ CD62L-单核细胞%单核细胞(cDC)与AS发病机制之间的重要因果关系也被揭示出来。对于PCOS,我们建立了40个因果效应,其中b细胞组中的CD20、CD24和CD27在PCOS中发挥着不同的作用。CM上的CD4+ (t细胞成熟阶段)显著增加PCOS的风险。对于SA,确定了33种病因关联,并特别注意到CCR2 (C-C趋化因子受体2型)对SA中CD14+ CD16+单核细胞(单核细胞组)的保护作用。CD28、CD39和CD25分子在SA的Treg细胞组中的不同功能也被观察到。结论:本研究全面评价了免疫性状与生殖疾病的因果关系,强调了免疫原性因素在发病机制中的复杂和重要作用,为临床工作指明了新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.

Background: Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.

Methods: Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.

Results: For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between CD11c+ CD62L- monocyte%monocyte (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. CD4 on CM CD4+ (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.

Conclusion: This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信