Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo
{"title":"免疫细胞对生殖疾病的因果影响,包括异常精子、多囊卵巢综合征和自然流产:孟德尔随机分析。","authors":"Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo","doi":"10.2147/JMDH.S524949","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.</p><p><strong>Methods: </strong>Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.</p><p><strong>Results: </strong>For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between <i>CD11c+ CD62L- monocyte%monocyte</i> (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. <i>CD4 on CM CD4+</i> (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of <i>CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes</i> (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.</p><p><strong>Conclusion: </strong>This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3219-3232"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151076/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.\",\"authors\":\"Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo\",\"doi\":\"10.2147/JMDH.S524949\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.</p><p><strong>Methods: </strong>Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.</p><p><strong>Results: </strong>For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between <i>CD11c+ CD62L- monocyte%monocyte</i> (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. <i>CD4 on CM CD4+</i> (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of <i>CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes</i> (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.</p><p><strong>Conclusion: </strong>This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.</p>\",\"PeriodicalId\":16357,\"journal\":{\"name\":\"Journal of Multidisciplinary Healthcare\",\"volume\":\"18 \",\"pages\":\"3219-3232\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151076/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Multidisciplinary Healthcare\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JMDH.S524949\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S524949","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.
Background: Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.
Methods: Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.
Results: For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between CD11c+ CD62L- monocyte%monocyte (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. CD4 on CM CD4+ (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.
Conclusion: This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.
期刊介绍:
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.