中国维吾尔族含硫饮食和CTH多态性与骨密度关系的初步研究

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S522804

Lingna Fang, Zhiqin Zhang, Dawei He, Yanming Hao, Yan Gao, Rongzhu Lu, Chong Li

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引用次数: 0

摘要

背景：本研究的目的是研究含硫饮食和CTH多态性(G1208T；Rs1021737)骨密度。方法：从中国新疆招募200名年龄在50岁以上的维吾尔族居民进行研究。收集参与者的空腹血液样本，测量血清硫化氢（H2S）水平，并进行CTH多态性测序。使用食物频率问卷评估膳食硫摄入量，并将其分为动物蛋白来源和非动物蛋白来源。用定量超声扫描评价跟骨的骨骼健康状况。结果：该研究共纳入200名参与者，其中男性81人，女性119人。根据骨量减少的情况对参与者进行分层，t评分≥-1.0表示骨密度正常，t评分< -1.0表示骨量减少。骨质减少组的个体表现出明显较低的骨密度标记，包括宽带超声衰减（BUA）和声速（SOS），以及较低的每周总膳食硫摄入量和每周动物蛋白硫摄入量。此外，与骨密度正常的参与者相比，他们的血清H2S水平明显更高。然而，在正常骨密度组和骨质减少组之间没有观察到CTH基因型的差异。根据每周从动物蛋白中摄取的硫，参与者被进一步分为三组（Q1至Q3）。与Q1组相比，Q3组的t评分和BUA值显著高于Q1组。二元logistic回归分析显示，低、中周动物蛋白硫摄入量组与高周动物蛋白硫摄入量组相比，骨质减少的风险分别高出3.252倍和4.330倍。结论：饲粮中动物蛋白中硫的摄入可能对骨密度有保护作用。

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Association of a Sulfur-Containing Diet and a CTH Polymorphism with Bone Density in the Uyghur Population of China: A Preliminary Study.

Background: The aim of this study was to examine the impact of a sulfur-containing diet and a CTH polymorphism (G1208T; rs1021737) on bone density.

Methods: A total of 200 Uyghur residents aged over 50 from Xinjiang, China, were recruited for this study. Fasting blood samples were collected from the participants to measure serum hydrogen sulfide (H₂S) levels and perform CTH polymorphism sequencing. Dietary sulfur intake was assessed using a food frequency questionnaire and categorized into animal protein-derived and non-animal protein-derived sources. Skeletal health of the calcaneus was evaluated using quantitative ultrasound scanning.

Results: The study included a total of 200 participants, comprising 81 males and 119 females. Participants were stratified based on osteopenia status, with a T-score ≥ -1.0 indicating normal bone density and a T-score < -1.0 indicating osteopenia. Individuals in the osteopenia group exhibited significantly lower bone density markers, including broadband ultrasound attenuation (BUA) and speed of sound (SOS), as well as lower total weekly dietary sulfur intake and weekly dietary sulfur intake from animal protein. Additionally, they had significantly higher serum H₂S levels compared to participants with normal bone density. However, no differences in CTH genotype were observed between the normal bone density group and the osteopenia group. Participants were further categorized into tertiles (Q1 to Q3) based on weekly dietary sulfur intake from animal protein. Compared to the Q1 group, the Q3 group showed significantly higher T-scores and BUA values. Binary logistic regression analysis revealed that, compared to the group with high weekly dietary sulfur intake from animal protein, the low and middle intake groups had 3.252 times and 4.330 times higher risks of osteopenia, respectively.

Conclusion: Dietary sulfur intake from animal protein may exert a protective effect on bone density.

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.