早产儿第三天体重变化与支气管肺发育不良风险：一项队列研究

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI:10.3389/fped.2025.1592069

Wenqian Chen, Wenhong Cai, Zhen Lin, Xiaofeng Ye, Bingjie Chen, Susu Mei, Tingting Huang, Yanli Ren

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引用次数: 0

摘要

目的：出生后早期的体液平衡和体重变化是新生儿适应的关键指标，并与早产儿并发症的发生有关。然而，早期体重变化与支气管肺发育不良（BPD）风险之间的关系尚不清楚。本研究旨在评估出生后第三天体重变化与早产儿BPD风险之间的关系。研究设计：一项包括早产儿的回顾性队列研究结果：在453名婴儿中，97.4% （n = 441）的体重变化在-15%至5%之间，BPD发病率为34.2%。第3天体重变化每增加1%与BPD风险增加10%相关（OR = 1.10, 95% CI: 1.03-1.18）。体重未减轻的婴儿患BPD的风险高出2.52倍（OR = 2.52, 95% CI: 1.34-4.80）。结论：第3天体重减轻与早产儿BPD风险降低有关。第3天的体重变化是一种无创且简单的BPD早期预测指标，优化早期体液管理以指导适当的体重变化可能有助于降低BPD的发病率。

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Third-day weight changes and bronchopulmonary dysplasia risk in preterm infants: a cohort study.

Objective: Fluid balance and weight changes in the early postnatal period are critical indicators of neonatal adaptation and have been implicated in the development of complications in preterm infants. However, the relationship between early weight changes and the risk of bronchopulmonary dysplasia (BPD) remains unclear. This study aimed to evaluate the association between weight change by the third day of life and the subsequent risk of BPD in preterm infants.

Study design: A retrospective cohort study included preterm infants <32 weeks gestation or <1,500 g birth weight. Logistic regression was used to assess the association between weight change by day 3 (percentage change from birth weight) and BPD.

Results: Among 453 infants, 97.4% (n = 441) had weight changes between -15% and 5%, with a BPD incidence of 34.2%. Each 1% increase in weight change by day 3 was linked to a 10% increase in BPD risk (OR = 1.10, 95% CI: 1.03-1.18). Infants without weight loss had a 2.52-fold higher BPD risk (OR = 2.52, 95% CI: 1.34-4.80).

Conclusion: Weight loss byday 3 is associated with a lower BPD risk in preterm infants. The day 3 weight change is a noninvasive and simple early predictor of BPD, and optimizing early fluid management to guide appropriate weight changes may help reduce BPD incidence.

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.