利比里亚2022-2023年疫情期间住院拉沙热病例的流行病学特征和住院结果

Q2 Pharmacology, Toxicology and Pharmaceutics

F1000Research Pub Date : 2025-06-10 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.150743.2

Emmanuel Dwalu, Hannock Tweya, Mher Beglaryan, Chukwuma D Umeokonkwo, Ralph W Jetoh, Bode I Shobayo, Fahn Tarweh, Philip Owiti, Pryanka Relan, Shermarke Hassan, George W Goteh, Darius B Lehyen, Louis Ako-Egbe, Ibrahim Franklyn Kamara, Godwin E Akpan, Peter Adewuyi, Patrick N Kpanyen, Benjamin T Vonhm, Julius S M Gilayeneh

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引用次数: 0

摘要

背景：拉沙热是利比里亚的一种地方病和应立即通报的疾病，一个实验室确诊病例构成疫情。我们描述了2022-2023年利比里亚疫情期间住院的LF病例的流行病学特征和医院结局。方法：利用利比里亚2022-2023年疫情的常规LF监测数据进行回顾性队列研究。采用描述性统计对资料进行汇总，并采用对数二项回归评估流行病学特征与死亡率之间的关系。结果：共报告疑似LF病例439例。年龄中位数为22岁（四分位间距：10-33岁），女性233例（53%）。从症状出现到入院的中位天数为4天（IQR 2-7）。439例中，416例（95%）检测了LF， 138例确诊，阳性率为33%。结论：此次暴发突出了LF的高疾病负担，年轻人感染比例过高，死亡率也很高，即使在病毒检测呈阴性的人群中也是如此。这突出表明迫切需要采取预防措施，如接种疫苗和开展健康教育运动。

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Epidemiological characteristics and hospital outcomes of hospitalized Lassa fever cases during the 2022-2023 outbreak in Liberia.

Background: Lassa fever (LF) is an endemic and immediately notifiable disease in Liberia, and one laboratory confirmed case constitutes an outbreak. We described the epidemiological characteristics and hospital outcomes of LF cases hospitalized during the 2022-2023 outbreak in Liberia.

Methods: A retrospective cohort study was conducted using routine LF surveillance data from the 2022-2023 outbreak in Liberia. Descriptive statistics were used to summarize the data and log binomial regression to assess the association between epidemiological characteristics and mortality.

Results: A total of 439 suspected LF cases were reported. The median age was 22 (interquartile range (IQR): 10-33) years and 233 (53%) were females. The median number of days between symptom onset and admission was 4 (IQR 2-7). Of the 439 cases, 416 (95%) were tested for LF and 138 were confirmed with 33% positivity rate. The majority, 95 (69%), of confirmed cases were <30 years, 78 (57%) were females, and 81 (59%) were reported during the dry season (October - March). Contact with rodents, 95 (69%), was the commonest mode of exposure. Fever, 128 (93%), malaise, 121 (88%), headache, 114 (83%) and myalgia, 114 (83%) were the most common clinical presentations. There were 83 (19%) deaths among hospitalized suspected LF cases - 42 deaths (15%) among 278 individuals who tested negative and 41 among confirmed cases with 30% case fatality rate (CFR). Presenting CFR per age group, age 40-49 years accounted for 8/12 (67%) and those aged≥50 reported 5/8 (63%) of the deaths among the confirmed cases. There was no significant association between epidemiological characteristics and LF mortality.

Conclusions: The outbreak highlighted a high disease burden of LF with young adults disproportionately infected, and mortality, even among those who tested negative for the virus. This underscores the urgent need for preventive measures like vaccines and health education campaigns.

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来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

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