原发性免疫性血小板减少症患者粪便微生物群与皮质类固醇反应性的相关性：一项探索性研究（科学进展，22/2025）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-06-12 DOI:10.1002/advs.202570168

Feng-Qi Liu, Zhuo-Yu An, Li-Juan Cui, Meng-Yu Xiao, Ye-Jun Wu, Wei Li, Bang-Shuo Zhang, Li Yu, Jia Feng, Zhuo-Gang Liu, Ru Feng, Zhong-Xing Jiang, Rui-Bin Huang, Hong-Mei Jing, Jin-Hai Ren, Xiao-Yu Zhu, Yun-Feng Cheng, Yu-Hua Li, He-Bing Zhou, Da Gao, Yi Liu, Fan Yu, Xin Wang, Jian-Lin Qiao, Dai-Hong Hu, Lu-Lu Wang, Meng-Tong Zang, Qi Chen, Qing-Yuan Qu, Jian-Ying Zhou, Meng-Lin Li, Yu-Xiu Chen, Qiu-Sha Huang, Hai-Xia Fu, Yue-Ying Li, Qian-Fei Wang, Xiao-Jun Huang, Xiao-hui Zhang, the Cooperative ITP Working Group

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引用次数: 0

摘要

免疫性血小板减少免疫性血小板减少症（ITP）的特征是脾血小板破坏和巨核细胞成熟功能障碍。新兴研究表明，分析肠道微生物组概况和临床参数的机器学习框架可以通过微生物-免疫轴调节可靠地预测对皮质类固醇的治疗反应。这种预测建模方法可以实现ITP护理的个性化治疗策略，通过计算生物标志物集成推进精确血液学。更多的细节可以在文章编号2410417中找到由小惠张和合作者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study (Adv. Sci. 22/2025)

Immune Thrombocytopenia

Immune thrombocytopenia (ITP) is characterized by splenic platelet destruction and dysfunctional megakaryocyte maturation. Emerging research demonstrates that machine learning frameworks analyzing gut microbiome profiles and clinical parameters can reliably forecast treatment responses to corticosteroids through microbiota-immune axis modulation. This predictive modeling approach enables personalized therapeutic strategies in ITP care, advancing precision hematology through computational biomarker integration. More details can be found in article number 2410417 by Xiao-hui Zhang and co-worders.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.