Ancong Wang, Fengxia Wu, Min Liu, Zhenchun Zhang, Shuxia Li, Qihua Tan
{"title":"抗核抗体阳性复发性自然流产的治疗及妊娠结局分析","authors":"Ancong Wang, Fengxia Wu, Min Liu, Zhenchun Zhang, Shuxia Li, Qihua Tan","doi":"10.1002/iid3.70216","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The etiology of recurrent spontaneous abortion (RSA) has not been clearly defined. The role of autoantibodies in RSA has particularly attracted much attention.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>A retrospective analysis was performed to explore the combinatory efficacy of five drugs (aspirin enteric-coated tablets, hydroxychloroquine sulfate, methylprednisolone tablets, calcitriol capsules, and vitamin D calcium) in treating RSA patients with antinuclear antibody (ANA)-positive but could not be diagnosed with autoimmune diseases (AID) through assessment of treatment-related impact on subsequent pregnancy outcomes and adverse reactions.</p>\n </section>\n \n <section>\n \n <h3> Method of the Study</h3>\n \n <p>Patients who took medication regularly were defined as the observation group (125 cases), and patients who did not take medication or took medication less than 1 month as the control group (86 cases). According to the ANA titer, patients were further divided into subgroups of 1:100, 1:320, and 1:1000, respectively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Comparison of the observation and the control groups without ANA subgrouping showed that the live birth rate in the observation group was higher (odds ratio 3.312, <i>p</i> < 0.001), and the miscarriage rate was lower than that of the control group (odds ratio 0.302, <i>p</i> < 0.001). Statistically significant results were obtained in ANA titer 1:100 subgrouping (<i>p</i> < 0.001). There was no significant difference between the observation groups and the control groups for the ANA titers 1:320 and 1:1000. No statistically significant differences were observed in pregnancy rate, birthweight, neonatal 1-min Apgar score, and incidence of pregnancy complications between the observation and the control groups. Besides, the treatment showed a low incidence of adverse effects.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In summary, RSA patients who are ANA positive (titer 1:100) but not yet diagnosed as AID can have improved pregnancy outcomes after treatment.</p>\n </section>\n </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 6","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70216","citationCount":"0","resultStr":"{\"title\":\"Analysis of Treatment and Subsequent Pregnancy Outcomes in Patients With Antinuclear Antibody-Positive Recurrent Spontaneous Abortion\",\"authors\":\"Ancong Wang, Fengxia Wu, Min Liu, Zhenchun Zhang, Shuxia Li, Qihua Tan\",\"doi\":\"10.1002/iid3.70216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The etiology of recurrent spontaneous abortion (RSA) has not been clearly defined. The role of autoantibodies in RSA has particularly attracted much attention.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>A retrospective analysis was performed to explore the combinatory efficacy of five drugs (aspirin enteric-coated tablets, hydroxychloroquine sulfate, methylprednisolone tablets, calcitriol capsules, and vitamin D calcium) in treating RSA patients with antinuclear antibody (ANA)-positive but could not be diagnosed with autoimmune diseases (AID) through assessment of treatment-related impact on subsequent pregnancy outcomes and adverse reactions.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Method of the Study</h3>\\n \\n <p>Patients who took medication regularly were defined as the observation group (125 cases), and patients who did not take medication or took medication less than 1 month as the control group (86 cases). According to the ANA titer, patients were further divided into subgroups of 1:100, 1:320, and 1:1000, respectively.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Comparison of the observation and the control groups without ANA subgrouping showed that the live birth rate in the observation group was higher (odds ratio 3.312, <i>p</i> < 0.001), and the miscarriage rate was lower than that of the control group (odds ratio 0.302, <i>p</i> < 0.001). Statistically significant results were obtained in ANA titer 1:100 subgrouping (<i>p</i> < 0.001). There was no significant difference between the observation groups and the control groups for the ANA titers 1:320 and 1:1000. No statistically significant differences were observed in pregnancy rate, birthweight, neonatal 1-min Apgar score, and incidence of pregnancy complications between the observation and the control groups. Besides, the treatment showed a low incidence of adverse effects.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>In summary, RSA patients who are ANA positive (titer 1:100) but not yet diagnosed as AID can have improved pregnancy outcomes after treatment.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13289,\"journal\":{\"name\":\"Immunity, Inflammation and Disease\",\"volume\":\"13 6\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70216\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunity, Inflammation and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iid3.70216\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunity, Inflammation and Disease","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iid3.70216","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Analysis of Treatment and Subsequent Pregnancy Outcomes in Patients With Antinuclear Antibody-Positive Recurrent Spontaneous Abortion
Background
The etiology of recurrent spontaneous abortion (RSA) has not been clearly defined. The role of autoantibodies in RSA has particularly attracted much attention.
Objective
A retrospective analysis was performed to explore the combinatory efficacy of five drugs (aspirin enteric-coated tablets, hydroxychloroquine sulfate, methylprednisolone tablets, calcitriol capsules, and vitamin D calcium) in treating RSA patients with antinuclear antibody (ANA)-positive but could not be diagnosed with autoimmune diseases (AID) through assessment of treatment-related impact on subsequent pregnancy outcomes and adverse reactions.
Method of the Study
Patients who took medication regularly were defined as the observation group (125 cases), and patients who did not take medication or took medication less than 1 month as the control group (86 cases). According to the ANA titer, patients were further divided into subgroups of 1:100, 1:320, and 1:1000, respectively.
Results
Comparison of the observation and the control groups without ANA subgrouping showed that the live birth rate in the observation group was higher (odds ratio 3.312, p < 0.001), and the miscarriage rate was lower than that of the control group (odds ratio 0.302, p < 0.001). Statistically significant results were obtained in ANA titer 1:100 subgrouping (p < 0.001). There was no significant difference between the observation groups and the control groups for the ANA titers 1:320 and 1:1000. No statistically significant differences were observed in pregnancy rate, birthweight, neonatal 1-min Apgar score, and incidence of pregnancy complications between the observation and the control groups. Besides, the treatment showed a low incidence of adverse effects.
Conclusion
In summary, RSA patients who are ANA positive (titer 1:100) but not yet diagnosed as AID can have improved pregnancy outcomes after treatment.
期刊介绍：
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
