利用改进的超声响应微泡靶向STING激活增强免疫检查点阻断黑色素瘤（Adv. Sci. 22/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-06-12 DOI:10.1002/advs.202570173

Sina Khorsandi, Kristin Huntoon, Yifan Wang, Adam Woodward, Abin Antony, Connor Endsley, Nazia Hafeez, Jared L. Edwards, Nicole McCuen, Prasanna G. Alluri, Betty Y.S. Kim, Wen Jiang, Jacques Lux

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引用次数: 0

摘要

癌症治疗：在抗体受体结合的引导下，充满气体的微泡选择性地靶向apc。超声脉冲在肿瘤部位触发微泡振荡和破裂，产生机械力，暂时破坏APC膜。这一过程使STING激动剂能够通过声共振有效地胞质内递送，绕过内体屏障，增强细胞内药物的免疫激活可用性。更多细节可以在文江、雅克·勒克斯和同事的文章2416596中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeted STING Activation Using Modified Ultrasound-Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025)

查看原文本刊更多论文

Targeted STING Activation Using Modified Ultrasound-Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025)

Cancer Therapy

Gas-filled microbubbles, guided by antibody-receptor binding, selectively target APCs. Ultrasound pulses at the tumor site trigger microbubble oscillation and collapse, generating mechanical forces that transiently disrupt the APC membrane. This process enables efficient cytosolic delivery of STING agonists via sonoporation, bypassing endosomal barriers and enhancing intracellular drug availability for immune activation. More details can be found in article number 2416596 by Wen Jiang, Jacques Lux, and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.