Advancements of multifunctional hydrogels in treating periodontal diseases: A concise review

Periodontal disease, stemming from dental plaque, poses challenges in treatment due to its multifaceted nature involving bacteria and oxidative stress. While mechanical therapy remains central, studies indicate the potential benefit of targeting both factors simultaneously. Hydrogels, with their advantageous properties, have emerged as promising biomaterials for periodontal therapy. Specifically, hydrogels incorporating antimicrobials and antioxidants present a viable treatment modality. This review systematically summarizes the latest research and application or implementation of multifunctional hydrogels, including chitosan and cellulose-based materials, in periodontal disease management. By offering insights into these novel approaches, this review aims to inspire innovative strategies for mitigating periodontal damage.