普罗帕酮引起的广泛复杂心动过速和布鲁加达心电图模式：一种罕见和不可预测的促心律失常效应

IF 1.2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of electrocardiology Pub Date : 2025-06-06 DOI:10.1016/j.jelectrocard.2025.154031

Acácio Fernandes Cardoso , Luiz Claudio Behrmann Martins , Cynthia Aparecida da Silva Rocha , Nemer Luiz Pichara , Kjell Nikus , Andrés Ricardo Pérez-Riera

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引用次数: 0

摘要

普罗帕酮是一种IC类抗心律失常药物，在世界范围内用于房颤的心律控制策略，包括拉丁美洲国家。普罗帕酮中毒是一种潜在的危及生命的疾病。室性心动过速和Brugada心电图（ECG）模式可能是普罗帕酮中毒的促心律失常表现。我们提出一个罕见的病例，在治疗范围内的普罗帕酮剂量导致广泛的复杂心动过速，其次是Brugada心电图模式心房颤动。我们讨论与这种异常心电图表现相关的可能机制。

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Wide complex tachycardia and brugada electrocardiographic pattern induced by propafenone: A rare and unpredictable pro-arrhythmic effect

Propafenone is a class IC anti-arrhythmic drug used for the rhythm control strategy in atrial fibrillation worldwide, including in Latin America countries. Propafenone intoxication is a potentially life-threatening condition. Ventricular tachycardia and the Brugada electrocardiographic (ECG) pattern are possible pro-arrhythmic manifestations of propafenone poisoning. We present a rare patient case, where therapeutic range dosage of propafenone resulted in a wide complex tachycardia, followed by the Brugada ECG pattern during atrial fibrillation. We discuss the possible mechanisms related to this unusual ECG manifestation.

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来源期刊

Journal of electrocardiology 医学-心血管系统

CiteScore

2.70

自引率

7.70%

发文量

152

审稿时长

38 days

期刊介绍： The Journal of Electrocardiology is devoted exclusively to clinical and experimental studies of the electrical activities of the heart. It seeks to contribute significantly to the accuracy of diagnosis and prognosis and the effective treatment, prevention, or delay of heart disease. Editorial contents include electrocardiography, vectorcardiography, arrhythmias, membrane action potential, cardiac pacing, monitoring defibrillation, instrumentation, drug effects, and computer applications.