脑源性神经营养因子与老年人内在能力的横断面关联：氧化应激的中介作用

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-06-12 DOI:10.1016/j.jnha.2025.100599

Chi Zhang , Ping Zeng , Yushan Zhang , Yuting Kang , Jie Zhang , Jing Li , Hong Shi , Shiwei Liu , Ji Shen

{"title":"脑源性神经营养因子与老年人内在能力的横断面关联：氧化应激的中介作用","authors":"Chi Zhang , Ping Zeng , Yushan Zhang , Yuting Kang , Jie Zhang , Jing Li , Hong Shi , Shiwei Liu , Ji Shen","doi":"10.1016/j.jnha.2025.100599","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 658 community-dwelling older adults (70.38 ± 6.06 years, 59.42% female). Intrinsic capacity including five domains was evaluated according to the World Health Organization recommendation. Plasma BDNF, high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1 beta (IL-1β), Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Glutathione reductase (GR)were measured by enzyme-linked immunosorbent assay methods. Restricted cubic spline and multivariate logistic regression were conducted to explore the association of BDNF with IC impairment. Mediation analyses were used to explore the potential mechanisms. Demographic characteristics, health behaviors, and comorbidities were included as covariates.</div></div><div><h3>Results</h3><div>247(37.54%) participants had IC impairment. Older individuals with impaired IC had lower levels of BDNF, IL-1β, SOD, and GR, while showed higher levels of hs-CRP and MDA compared to the normal group. There was an L-shaped negative correlation between BDNF levels and the odds of IC impairment (<em>P</em>-nonlinear <0.001). After adjusting for all confounders, the odds for IC impairment in the medium and high BDNF tertiles were significantly lower than in the low BDNF tertile, with ORs of 0.43(95% CI: 0.26−0.89, <em>P</em> = 0.004) and 0.38(95% CI: 0.20−0.71, <em>P</em> = 0.007), respectively. Plasma SOD and GR mediated 4.13% (95% CI: 1.15, 7.16) and 7.82% (95% CI: 3.24, 12.48) of the total effect of BDNF on IC.</div></div><div><h3>Conclusion</h3><div>High levels of circulatory BDNF may be related to lower odds of IC impairment. Oxidative stress status partially explains the mechanisms underlying the association.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100599"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress\",\"authors\":\"Chi Zhang , Ping Zeng , Yushan Zhang , Yuting Kang , Jie Zhang , Jing Li , Hong Shi , Shiwei Liu , Ji Shen\",\"doi\":\"10.1016/j.jnha.2025.100599\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 658 community-dwelling older adults (70.38 ± 6.06 years, 59.42% female). Intrinsic capacity including five domains was evaluated according to the World Health Organization recommendation. Plasma BDNF, high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1 beta (IL-1β), Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Glutathione reductase (GR)were measured by enzyme-linked immunosorbent assay methods. Restricted cubic spline and multivariate logistic regression were conducted to explore the association of BDNF with IC impairment. Mediation analyses were used to explore the potential mechanisms. Demographic characteristics, health behaviors, and comorbidities were included as covariates.</div></div><div><h3>Results</h3><div>247(37.54%) participants had IC impairment. Older individuals with impaired IC had lower levels of BDNF, IL-1β, SOD, and GR, while showed higher levels of hs-CRP and MDA compared to the normal group. There was an L-shaped negative correlation between BDNF levels and the odds of IC impairment (<em>P</em>-nonlinear <0.001). After adjusting for all confounders, the odds for IC impairment in the medium and high BDNF tertiles were significantly lower than in the low BDNF tertile, with ORs of 0.43(95% CI: 0.26−0.89, <em>P</em> = 0.004) and 0.38(95% CI: 0.20−0.71, <em>P</em> = 0.007), respectively. Plasma SOD and GR mediated 4.13% (95% CI: 1.15, 7.16) and 7.82% (95% CI: 3.24, 12.48) of the total effect of BDNF on IC.</div></div><div><h3>Conclusion</h3><div>High levels of circulatory BDNF may be related to lower odds of IC impairment. Oxidative stress status partially explains the mechanisms underlying the association.</div></div>\",\"PeriodicalId\":54778,\"journal\":{\"name\":\"Journal of Nutrition Health & Aging\",\"volume\":\"29 8\",\"pages\":\"Article 100599\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutrition Health & Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1279770725001241\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition Health & Aging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1279770725001241","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的脑源性神经营养因子（BDNF）是脑肌轴的关键指标。本研究旨在探讨老年人血浆BDNF与内在容量（IC）的关系，并探讨炎症和氧化应激的介导作用。方法对658名社区老年人（70.38±6.06岁，女性59.42%）进行横断面研究。根据世界卫生组织的建议，对包括五个领域在内的内在能力进行了评估。采用酶联免疫吸附法测定血浆BDNF、高敏c反应蛋白（hs-CRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GR）。通过限制三次样条和多元逻辑回归探讨BDNF与IC损伤的关系。采用中介分析探讨其潜在机制。结果247名（37.54%）参与者存在智力障碍。与正常组相比，IC受损的老年人BDNF、IL-1β、SOD和GR水平较低，而hs-CRP和MDA水平较高。BDNF水平与IC损伤几率呈l形负相关（p -非线性<；0.001）。在对所有混杂因素进行调整后，中等和高BDNF组IC损伤的几率显著低于低BDNF组，or分别为0.43（95% CI: 0.26 - 0.89, P = 0.004）和0.38（95% CI: 0.20 - 0.71, P = 0.007）。血浆SOD和GR分别介导了4.13% （95% CI: 1.15, 7.16）和7.82% （95% CI: 3.24, 12.48）的BDNF对IC的总影响。结论高水平的循环BDNF可能与较低的IC损害发生率有关。氧化应激状态部分解释了这种关联背后的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress

Objectives

Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.

Methods

This cross-sectional study included 658 community-dwelling older adults (70.38 ± 6.06 years, 59.42% female). Intrinsic capacity including five domains was evaluated according to the World Health Organization recommendation. Plasma BDNF, high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1 beta (IL-1β), Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Glutathione reductase (GR)were measured by enzyme-linked immunosorbent assay methods. Restricted cubic spline and multivariate logistic regression were conducted to explore the association of BDNF with IC impairment. Mediation analyses were used to explore the potential mechanisms. Demographic characteristics, health behaviors, and comorbidities were included as covariates.

Results

247(37.54%) participants had IC impairment. Older individuals with impaired IC had lower levels of BDNF, IL-1β, SOD, and GR, while showed higher levels of hs-CRP and MDA compared to the normal group. There was an L-shaped negative correlation between BDNF levels and the odds of IC impairment (P-nonlinear <0.001). After adjusting for all confounders, the odds for IC impairment in the medium and high BDNF tertiles were significantly lower than in the low BDNF tertile, with ORs of 0.43(95% CI: 0.26−0.89, P = 0.004) and 0.38(95% CI: 0.20−0.71, P = 0.007), respectively. Plasma SOD and GR mediated 4.13% (95% CI: 1.15, 7.16) and 7.82% (95% CI: 3.24, 12.48) of the total effect of BDNF on IC.

Conclusion

High levels of circulatory BDNF may be related to lower odds of IC impairment. Oxidative stress status partially explains the mechanisms underlying the association.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.