单剂量哌甲酯对帕金森病患者认知功能的电生理影响

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-06-06 DOI:10.1016/j.clinph.2025.2110781

Noa Fogelson , Estela Martinez Lopez , Mirian Roson Gonzalez , Miguel Fernandez-del-Olmo , Tanya Gurevich , Lydia Vela Desojo

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引用次数: 0

摘要

目的最近的研究表明，哌醋甲酯（MPD）可能对帕金森病（PD）患者有治疗作用，主要是在步态和冷漠方面。在一项随机、双盲、安慰剂对照、单剂量、交叉临床试验研究中，我们通过行为和电生理测量，检测了单剂量20mg MPD对非痴呆性PD患者的认知影响。方法对22例PD患者在ON状态下进行扩展版视觉奇球任务时的脑电图（EEG）进行记录。我们比较了预测和随机目标的处理，以及预测序列被利用的程度。以双盲、随机、平衡的方式对每位患者进行两次记录（20mg MPD或安慰剂），间隔7-14天。结果我们发现，与安慰剂组相比，单剂量MPD诱导的MPD中与任务相关的预测目标的P3b潜伏期更短。结论：与安慰剂相比，单剂量MPD诱导非痴呆PD患者对预测刺激的目标检测具有事件相关的促进作用。我们的研究结果表明，MPD可能通过增强PD中改变的自上而下的内源性控制过程，对血压正常的PD患者有有益的认知作用。

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Cognitive effects of a single dose of methylphenidate in Parkinson’s disease patients using electrophysiological measures

Objectives

Recent studies have suggested that methylphenidate (MPD) may have therapeutic effects in Parkinson’s disease (PD) patients, primarily on gait and apathy. We examined the cognitive effects of a single 20 mg dose of MPD in non-demented PD patients, using behavioral and electrophysiological measures, in a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial study.

Methods

To this end, we recorded electroencephalography (EEG) in twenty-two PD patients during the performance of an extended version of a visual oddball task, while patients were in ON state. We compared the processing of predictive versus random targets, and the extent to which predictive sequences are utilized. Two recording sessions (20 mg of MPD or placebo) were performed in each patient, 7–14 days apart, in a double-blinded, randomized, counterbalanced manner.

Results

We found that a single-dose of MPD induced shorter P3b latencies for task-relevant predicted targets in the MPD compared to the placebo session.

Conclusions

A single-dose of MPD induced an event-related facilitation of target detection of predicted stimuli, compared to placebo, in non-demented patients with PD.

Significance

Our findings suggest that MPD may have beneficial cognitive effects in normotensive patients with PD, by enhancing top-down endogenous control processes, which are altered in PD.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.