盐诱导激酶（SIKs）抑制剂作为炎症、过敏、自身免疫、癌症和代谢疾病的新兴治疗方法

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-05-20 DOI:10.1021/acsmedchemlett.5c0027410.1021/acsmedchemlett.5c00274

Ahmed F. Abdel-Magid*,

{"title":"盐诱导激酶（SIKs）抑制剂作为炎症、过敏、自身免疫、癌症和代谢疾病的新兴治疗方法","authors":"Ahmed F. Abdel-Magid*, ","doi":"10.1021/acsmedchemlett.5c0027410.1021/acsmedchemlett.5c00274","DOIUrl":null,"url":null,"abstract":"The invention in this patent application relates to pyrazolo[1,5-a]pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and may be useful for the treatment of inflammatory, allergic, and autoimmune diseases. They can additionally be of potential relevance in treatment of cancer, metabolic diseases, bone density dysregulation diseases, pigmentation-related diseases or cosmetology, fibrotic diseases, and depressive disorders.","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":"16 6","pages":"952–954 952–954"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases\",\"authors\":\"Ahmed F. Abdel-Magid*, \",\"doi\":\"10.1021/acsmedchemlett.5c0027410.1021/acsmedchemlett.5c00274\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The invention in this patent application relates to pyrazolo[1,5-a]pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and may be useful for the treatment of inflammatory, allergic, and autoimmune diseases. They can additionally be of potential relevance in treatment of cancer, metabolic diseases, bone density dysregulation diseases, pigmentation-related diseases or cosmetology, fibrotic diseases, and depressive disorders.\",\"PeriodicalId\":20,\"journal\":{\"name\":\"ACS Medicinal Chemistry Letters\",\"volume\":\"16 6\",\"pages\":\"952–954 952–954\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Medicinal Chemistry Letters\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00274\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Medicinal Chemistry Letters","FirstCategoryId":"3","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00274","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

本专利申请中的发明涉及吡唑[1,5-a]吡啶衍生物，如式I和式II所示。这些化合物是高活性的SIK抑制剂，可能对治疗炎症、过敏和自身免疫性疾病有用。此外，它们还可能与癌症、代谢疾病、骨密度失调疾病、色素相关疾病或美容、纤维化疾病和抑郁症的治疗有潜在的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases

The invention in this patent application relates to pyrazolo[1,5-a]pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and may be useful for the treatment of inflammatory, allergic, and autoimmune diseases. They can additionally be of potential relevance in treatment of cancer, metabolic diseases, bone density dysregulation diseases, pigmentation-related diseases or cosmetology, fibrotic diseases, and depressive disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.