pd催化C-H活化和氧化环法制备n -甲氧基- 7h -铬喹啉酮和n -甲氧基苯基喹啉酮

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-06-11 DOI:10.1002/ejoc.202500107

Harishankar Behera, Suhasini Mohapatra, Sabita Nayak, Seetaram Mohapatra, Tapaswini Pati, Kamalika Prusty

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引用次数: 0

摘要

成功地研究了钯催化的n -甲氧基- 2h -铬-3-羧酰胺和n -甲氧基肉桂酰胺与苯通过C-H官能化反应合成n -甲氧基- 7h -铬-喹啉酮和n -甲氧基苯基喹啉酮。该反应显示出与不同底物的广泛相容性，对各种官能团的高耐受性和优异的区域选择性。通过仔细选择取代的芳烃，可以实现特殊的区域选择性。通过x射线晶体学确定了关键产物的结构，进一步验证了反应的效率和成功性。

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Pd-Catalyzed C-H Activation and Oxidative Annulation to Access N-methoxy-7H-Chromenoquinolinones and N-methoxyphenyl quinolinones

The palladium-catalyzed oxidative annulation of N-methoxy-2H-chromene-3-carboxamides and N-methoxycinnamamides with benzynes via C-H functionalization to synthesize N-methoxy-7H-Chromenoquinolinones and N-methoxyphenylquinolinones have been developed successfully. The reaction demonstrates broad compatibility with different substrates, high tolerance for various functional groups, and excellent regioselectivity. By carefully selecting substituted arynes, exceptional regioselectivity can be achieved. The structure of a key product was confirmed through X-ray crystallography, further validating the efficiency and success of the reaction.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.