{"title":"高频毛细管波驱动的超小液滴吸入给药技术","authors":"Haitao Zhang, Zirui Zhao, Yangchao Zhou, Zaoxian Mei, Xuexin Duan","doi":"10.1039/d5lc00390c","DOIUrl":null,"url":null,"abstract":"Benefiting from localization, targeting and rapid response, inhaled drug delivery has become an indispensable method for lung diseases treating. However, the efficacy of drug delivery is often compromised by the physical characteristics of the aerosol produced by current nebulization methods: large droplet size distributions, which is deposited in the upper airways. In this study, an appropriate size distributions, portable, low energy and low-cost approach is introduced to nebulize drug using capillary wave breakup induced by gigahertz (GHz) acoustic waves. A delicately designed miniaturized nebulizer is developed by integrating the GHz bulk acoustic resonator with semi-opened microchannel to nebulize droplets of optimal size for pulmonary inhalation, with size distributions that 96% are smaller than 5 μm at low power, that surpass existing methods. In addition, this technique facilitates the nebulization of liquids with viscosities up to 5000 cP. Low-flux lung models achieve 88% drug delivery efficiency. Murine in vivo tests demonstrate the efficacy of proposed nebulizer in lung-targeted delivery via autonomous inhalation, attributed to optimized droplet size and flux. The tunable sizes, broad range of nebulization viscosities, suitable fluxes, pumpless operation and low cost highlight the potential for autonomous lung drug delivery and combination therapy targeting both small airways and alveoli.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":"60 1","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High Frequency Capillary Wave Enabled Ultra-small Droplets for Inhaled Drug Delivery\",\"authors\":\"Haitao Zhang, Zirui Zhao, Yangchao Zhou, Zaoxian Mei, Xuexin Duan\",\"doi\":\"10.1039/d5lc00390c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Benefiting from localization, targeting and rapid response, inhaled drug delivery has become an indispensable method for lung diseases treating. However, the efficacy of drug delivery is often compromised by the physical characteristics of the aerosol produced by current nebulization methods: large droplet size distributions, which is deposited in the upper airways. In this study, an appropriate size distributions, portable, low energy and low-cost approach is introduced to nebulize drug using capillary wave breakup induced by gigahertz (GHz) acoustic waves. A delicately designed miniaturized nebulizer is developed by integrating the GHz bulk acoustic resonator with semi-opened microchannel to nebulize droplets of optimal size for pulmonary inhalation, with size distributions that 96% are smaller than 5 μm at low power, that surpass existing methods. In addition, this technique facilitates the nebulization of liquids with viscosities up to 5000 cP. Low-flux lung models achieve 88% drug delivery efficiency. Murine in vivo tests demonstrate the efficacy of proposed nebulizer in lung-targeted delivery via autonomous inhalation, attributed to optimized droplet size and flux. The tunable sizes, broad range of nebulization viscosities, suitable fluxes, pumpless operation and low cost highlight the potential for autonomous lung drug delivery and combination therapy targeting both small airways and alveoli.\",\"PeriodicalId\":85,\"journal\":{\"name\":\"Lab on a Chip\",\"volume\":\"60 1\",\"pages\":\"\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lab on a Chip\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1039/d5lc00390c\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab on a Chip","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1039/d5lc00390c","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
High Frequency Capillary Wave Enabled Ultra-small Droplets for Inhaled Drug Delivery
Benefiting from localization, targeting and rapid response, inhaled drug delivery has become an indispensable method for lung diseases treating. However, the efficacy of drug delivery is often compromised by the physical characteristics of the aerosol produced by current nebulization methods: large droplet size distributions, which is deposited in the upper airways. In this study, an appropriate size distributions, portable, low energy and low-cost approach is introduced to nebulize drug using capillary wave breakup induced by gigahertz (GHz) acoustic waves. A delicately designed miniaturized nebulizer is developed by integrating the GHz bulk acoustic resonator with semi-opened microchannel to nebulize droplets of optimal size for pulmonary inhalation, with size distributions that 96% are smaller than 5 μm at low power, that surpass existing methods. In addition, this technique facilitates the nebulization of liquids with viscosities up to 5000 cP. Low-flux lung models achieve 88% drug delivery efficiency. Murine in vivo tests demonstrate the efficacy of proposed nebulizer in lung-targeted delivery via autonomous inhalation, attributed to optimized droplet size and flux. The tunable sizes, broad range of nebulization viscosities, suitable fluxes, pumpless operation and low cost highlight the potential for autonomous lung drug delivery and combination therapy targeting both small airways and alveoli.
期刊介绍:
Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.