具有人类功能性免疫力的猪

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2025-06-11 DOI:10.1038/s41551-025-01426-4

Christopher K. Tuggle, Crystal L. Loving, Beau R. Webber

引用次数: 0

摘要

基因修饰的免疫缺陷猪支持功能性人类B细胞和T细胞的发育，代表了研究人类造血的临床前模型和大规模生产用于多种治疗的人类免疫细胞的生物反应器。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A pig with functional human immunity

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A pig with functional human immunity

Genetically modified immunodeficient pigs support the development of functional human B and T cells and represent a preclinical model for investigating human haematopoiesis and a bioreactor for large-scale production of human immune cells for diverse therapies.

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.