{"title":"供精体外受精中新鲜胚胎与首次冷冻解冻胚胎移植的结果。","authors":"Jiayao Chen, Zhiping Zhang, Wenjing Shi, Qin Yan, Shimin Wang, Xueqing Wu","doi":"10.29271/jcpsp.2025.06.703","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.</p><p><strong>Study design: </strong>Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.</p><p><strong>Methodology: </strong>Clinical data and pregnancy outcomes of 1,051 sperm-donor in-vitro fertilisation IVF/ICSI embryo-transfer cycles, divided into initial FET and fresh ET groups, were compared. Primary outcomes included clinical pregnancy rate, miscarriage rate, and live birth rate.</p><p><strong>Results: </strong>Significant differences were observed in clinical pregnancy and live birth rates (44.02% vs. 53.63%, p = 0.018; 34.78% vs. 44.87%, p = 0.012) but not in miscarriage or ectopic pregnancy rates (18.52% vs. 14.41%, p = 0.339; 2.47% vs. 1.94%, p = 0.752) between the groups.</p><p><strong>Conclusion: </strong>In 1,065 sperm-donor IVF cycles, frozen-thawed embryos yielded higher clinical pregnancy and live birth rates, particularly with single ET. FET is a successful, safe, and preferable option for couples using donor sperm in assisted reproductive technologies.</p><p><strong>Key words: </strong>Donor sperm, Fresh embryo transfer, Frozen-thawed embryo transfer, Pregnancy outcome, Assisted reproductive technique.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"703-707"},"PeriodicalIF":0.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation.\",\"authors\":\"Jiayao Chen, Zhiping Zhang, Wenjing Shi, Qin Yan, Shimin Wang, Xueqing Wu\",\"doi\":\"10.29271/jcpsp.2025.06.703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.</p><p><strong>Study design: </strong>Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.</p><p><strong>Methodology: </strong>Clinical data and pregnancy outcomes of 1,051 sperm-donor in-vitro fertilisation IVF/ICSI embryo-transfer cycles, divided into initial FET and fresh ET groups, were compared. Primary outcomes included clinical pregnancy rate, miscarriage rate, and live birth rate.</p><p><strong>Results: </strong>Significant differences were observed in clinical pregnancy and live birth rates (44.02% vs. 53.63%, p = 0.018; 34.78% vs. 44.87%, p = 0.012) but not in miscarriage or ectopic pregnancy rates (18.52% vs. 14.41%, p = 0.339; 2.47% vs. 1.94%, p = 0.752) between the groups.</p><p><strong>Conclusion: </strong>In 1,065 sperm-donor IVF cycles, frozen-thawed embryos yielded higher clinical pregnancy and live birth rates, particularly with single ET. FET is a successful, safe, and preferable option for couples using donor sperm in assisted reproductive technologies.</p><p><strong>Key words: </strong>Donor sperm, Fresh embryo transfer, Frozen-thawed embryo transfer, Pregnancy outcome, Assisted reproductive technique.</p>\",\"PeriodicalId\":94116,\"journal\":{\"name\":\"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP\",\"volume\":\"35 6\",\"pages\":\"703-707\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29271/jcpsp.2025.06.703\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29271/jcpsp.2025.06.703","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：在控制母体混杂因素后，比较胚胎移植（ET）与冻融胚胎移植（FET）的妊娠结局。研究设计：描述性分析研究。研究地点和时间：山西省儿童医院生殖医学中心和山西医科大学附属医院山西妇女健康中心，中国太原，2015年1月至2022年9月。方法：比较1051例精子供体体外受精IVF/ICSI胚胎移植周期的临床数据和妊娠结局，分为初始ET组和新鲜ET组。主要结局包括临床妊娠率、流产率和活产率。结果：两组临床妊娠率和活产率差异有统计学意义(44.02% vs. 53.63%, p = 0.018；34.78% vs. 44.87%, p = 0.012)，但流产和异位妊娠发生率无差异(18.52% vs. 14.41%, p = 0.339；2.47% vs. 1.94%, p = 0.752)。结论：在1065个精子供体体外受精周期中，冷冻解冻胚胎获得了更高的临床妊娠率和活产率，特别是单次ET。FET是一种成功、安全、更适合夫妇使用供体精子进行辅助生殖技术的选择。关键词：供体精子，新鲜胚胎移植，冻融胚胎移植，妊娠结局，辅助生殖技术
Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation.
Objective: To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.
Study design: Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.
Methodology: Clinical data and pregnancy outcomes of 1,051 sperm-donor in-vitro fertilisation IVF/ICSI embryo-transfer cycles, divided into initial FET and fresh ET groups, were compared. Primary outcomes included clinical pregnancy rate, miscarriage rate, and live birth rate.
Results: Significant differences were observed in clinical pregnancy and live birth rates (44.02% vs. 53.63%, p = 0.018; 34.78% vs. 44.87%, p = 0.012) but not in miscarriage or ectopic pregnancy rates (18.52% vs. 14.41%, p = 0.339; 2.47% vs. 1.94%, p = 0.752) between the groups.
Conclusion: In 1,065 sperm-donor IVF cycles, frozen-thawed embryos yielded higher clinical pregnancy and live birth rates, particularly with single ET. FET is a successful, safe, and preferable option for couples using donor sperm in assisted reproductive technologies.
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