Yukang Gong, Yanan Niu, Chenhao Wang, Gaoqi Ye, Menghang Chen, Gaokai Hu, Yang Hu, Yuhan Xue, Tao Guo, Wenjuan Yin, Yuangong Zhang, Zheng Gao, Feng Liu, Wenshan Gao
{"title":"聚多巴胺/蒙脱石基刷石磷酸钙水泥：骨再生的协同机械和成骨能力。","authors":"Yukang Gong, Yanan Niu, Chenhao Wang, Gaoqi Ye, Menghang Chen, Gaokai Hu, Yang Hu, Yuhan Xue, Tao Guo, Wenjuan Yin, Yuangong Zhang, Zheng Gao, Feng Liu, Wenshan Gao","doi":"10.34133/bmr.0213","DOIUrl":null,"url":null,"abstract":"<p><p>Although brushite calcium phosphate cements (Bru-CPCs) possess good bioactivity and biocompatibility, their low compressive strength hinders their effective application in osteoporotic bone defect treatment. Therefore, the aim of this study was to improve the compressive strength without sacrificing the osteogenesis properties of Bru-CPCs. Montmorillonite (MMT) was added into Bru-CPCs to get Bru-CPCs/1.5% MMT. The compressive strength of Bru-CPCs/1.5% MMT increased to 13.31 MPa, but the interfacial interactions between MMT and Bru-CPCs (inorganic-inorganic phase) limited further improvement in compressive strength. Inspired by the adhesive proteins in mussels, MMT was coated with a polydopamine (PDA) layer to get MMT@PDA. The compressive strength of Bru-CPCs/1.5% MMT@PDA further increased to 16.58 MPa. Then, the surface morphology, adhesiveness, biocompatibility, and bioactivity of CPCs/1.5% MMT@PDA were evaluated. All data indicated that by adding MMT@PDA, the compressive strength was improved without sacrificing the osteogenesis properties of Bru-CPCs.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0213"},"PeriodicalIF":8.1000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147390/pdf/","citationCount":"0","resultStr":"{\"title\":\"Polydopamine/Montmorillonite-Based Brushite Calcium Phosphate Cements: Synergize Mechanical and Osteogenic Capacity for Bone Regeneration.\",\"authors\":\"Yukang Gong, Yanan Niu, Chenhao Wang, Gaoqi Ye, Menghang Chen, Gaokai Hu, Yang Hu, Yuhan Xue, Tao Guo, Wenjuan Yin, Yuangong Zhang, Zheng Gao, Feng Liu, Wenshan Gao\",\"doi\":\"10.34133/bmr.0213\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Although brushite calcium phosphate cements (Bru-CPCs) possess good bioactivity and biocompatibility, their low compressive strength hinders their effective application in osteoporotic bone defect treatment. Therefore, the aim of this study was to improve the compressive strength without sacrificing the osteogenesis properties of Bru-CPCs. Montmorillonite (MMT) was added into Bru-CPCs to get Bru-CPCs/1.5% MMT. The compressive strength of Bru-CPCs/1.5% MMT increased to 13.31 MPa, but the interfacial interactions between MMT and Bru-CPCs (inorganic-inorganic phase) limited further improvement in compressive strength. Inspired by the adhesive proteins in mussels, MMT was coated with a polydopamine (PDA) layer to get MMT@PDA. The compressive strength of Bru-CPCs/1.5% MMT@PDA further increased to 16.58 MPa. Then, the surface morphology, adhesiveness, biocompatibility, and bioactivity of CPCs/1.5% MMT@PDA were evaluated. All data indicated that by adding MMT@PDA, the compressive strength was improved without sacrificing the osteogenesis properties of Bru-CPCs.</p>\",\"PeriodicalId\":93902,\"journal\":{\"name\":\"Biomaterials research\",\"volume\":\"29 \",\"pages\":\"0213\"},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147390/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34133/bmr.0213\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34133/bmr.0213","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Polydopamine/Montmorillonite-Based Brushite Calcium Phosphate Cements: Synergize Mechanical and Osteogenic Capacity for Bone Regeneration.
Although brushite calcium phosphate cements (Bru-CPCs) possess good bioactivity and biocompatibility, their low compressive strength hinders their effective application in osteoporotic bone defect treatment. Therefore, the aim of this study was to improve the compressive strength without sacrificing the osteogenesis properties of Bru-CPCs. Montmorillonite (MMT) was added into Bru-CPCs to get Bru-CPCs/1.5% MMT. The compressive strength of Bru-CPCs/1.5% MMT increased to 13.31 MPa, but the interfacial interactions between MMT and Bru-CPCs (inorganic-inorganic phase) limited further improvement in compressive strength. Inspired by the adhesive proteins in mussels, MMT was coated with a polydopamine (PDA) layer to get MMT@PDA. The compressive strength of Bru-CPCs/1.5% MMT@PDA further increased to 16.58 MPa. Then, the surface morphology, adhesiveness, biocompatibility, and bioactivity of CPCs/1.5% MMT@PDA were evaluated. All data indicated that by adding MMT@PDA, the compressive strength was improved without sacrificing the osteogenesis properties of Bru-CPCs.
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