Veronica L Richards, Kimberly A Mallett, Robert J Turrisi, Jason A Oliver, Julie M Croff, Michael A Russell
{"title":"尼古丁和酒精共同使用对大学生酒精引起的昏厥和其他酒精相关后果的影响。","authors":"Veronica L Richards, Kimberly A Mallett, Robert J Turrisi, Jason A Oliver, Julie M Croff, Michael A Russell","doi":"10.1007/s00213-025-06830-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale: </strong>Alcohol-induced blackouts (AIBs) are common in college students and are associated with other alcohol-related consequences. Alcohol-nicotine co-use is also common in this population. Nicotine has cognitive-enhancing properties impacting multiple cognitive domains, including those impaired by alcohol (e.g., attention), but it is unclear whether nicotine affects AIB risk or the relationship between AIBs and other alcohol-related consequences.</p><p><strong>Objectives: </strong>We examined the moderating effects of nicotine use on the associations between (a) alcohol and AIBs and (b) AIBs and other consequences (total and serious: sexual, legal, or those with potential to cause great harm).</p><p><strong>Methods: </strong>College students who reported past semester heavy drinking and at least 1 AIB (N = 79, 55.7% female, 86.1% White) wore alcohol sensors and completed daily diaries over four consecutive weekends (89.9% completion). Multilevel models were conducted to test for moderating effects of nicotine (yes/no) on the alcohol-AIB relationship and the AIB-consequence relationship, adjusting for sex, race/ethnicity, and baseline nicotine use.</p><p><strong>Results: </strong>Concurrent alcohol and nicotine use did not moderate the alcohol-AIB relationship, but weakened the associations between AIBs and both (1) total consequences and (2) serious consequences. On days with nicotine use, AIBs were associated with approximately 30% fewer total consequences and 50% fewer serious consequences than days without nicotine use.</p><p><strong>Conclusions: </strong>College students experienced fewer total and serious consequences on AIB nights when nicotine was used compared to AIB nights when nicotine was not used. Future research should explore potential mechanisms underlying the observed effects.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of nicotine-alcohol co-use on alcohol-induced blackouts and other alcohol-related consequences in college students.\",\"authors\":\"Veronica L Richards, Kimberly A Mallett, Robert J Turrisi, Jason A Oliver, Julie M Croff, Michael A Russell\",\"doi\":\"10.1007/s00213-025-06830-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>Alcohol-induced blackouts (AIBs) are common in college students and are associated with other alcohol-related consequences. Alcohol-nicotine co-use is also common in this population. Nicotine has cognitive-enhancing properties impacting multiple cognitive domains, including those impaired by alcohol (e.g., attention), but it is unclear whether nicotine affects AIB risk or the relationship between AIBs and other alcohol-related consequences.</p><p><strong>Objectives: </strong>We examined the moderating effects of nicotine use on the associations between (a) alcohol and AIBs and (b) AIBs and other consequences (total and serious: sexual, legal, or those with potential to cause great harm).</p><p><strong>Methods: </strong>College students who reported past semester heavy drinking and at least 1 AIB (N = 79, 55.7% female, 86.1% White) wore alcohol sensors and completed daily diaries over four consecutive weekends (89.9% completion). Multilevel models were conducted to test for moderating effects of nicotine (yes/no) on the alcohol-AIB relationship and the AIB-consequence relationship, adjusting for sex, race/ethnicity, and baseline nicotine use.</p><p><strong>Results: </strong>Concurrent alcohol and nicotine use did not moderate the alcohol-AIB relationship, but weakened the associations between AIBs and both (1) total consequences and (2) serious consequences. On days with nicotine use, AIBs were associated with approximately 30% fewer total consequences and 50% fewer serious consequences than days without nicotine use.</p><p><strong>Conclusions: </strong>College students experienced fewer total and serious consequences on AIB nights when nicotine was used compared to AIB nights when nicotine was not used. 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Effects of nicotine-alcohol co-use on alcohol-induced blackouts and other alcohol-related consequences in college students.
Rationale: Alcohol-induced blackouts (AIBs) are common in college students and are associated with other alcohol-related consequences. Alcohol-nicotine co-use is also common in this population. Nicotine has cognitive-enhancing properties impacting multiple cognitive domains, including those impaired by alcohol (e.g., attention), but it is unclear whether nicotine affects AIB risk or the relationship between AIBs and other alcohol-related consequences.
Objectives: We examined the moderating effects of nicotine use on the associations between (a) alcohol and AIBs and (b) AIBs and other consequences (total and serious: sexual, legal, or those with potential to cause great harm).
Methods: College students who reported past semester heavy drinking and at least 1 AIB (N = 79, 55.7% female, 86.1% White) wore alcohol sensors and completed daily diaries over four consecutive weekends (89.9% completion). Multilevel models were conducted to test for moderating effects of nicotine (yes/no) on the alcohol-AIB relationship and the AIB-consequence relationship, adjusting for sex, race/ethnicity, and baseline nicotine use.
Results: Concurrent alcohol and nicotine use did not moderate the alcohol-AIB relationship, but weakened the associations between AIBs and both (1) total consequences and (2) serious consequences. On days with nicotine use, AIBs were associated with approximately 30% fewer total consequences and 50% fewer serious consequences than days without nicotine use.
Conclusions: College students experienced fewer total and serious consequences on AIB nights when nicotine was used compared to AIB nights when nicotine was not used. Future research should explore potential mechanisms underlying the observed effects.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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