Sara Haydar, Camilla Cederbye Karlsson, Allan Linneberg, Line Lund Kårhus, Lars Ängquist, Oluf Pedersen, Wender Bredie, Torben Hansen, Niels Grarup
{"title":"丹麦人味觉喜好的全基因组关联研究。","authors":"Sara Haydar, Camilla Cederbye Karlsson, Allan Linneberg, Line Lund Kårhus, Lars Ängquist, Oluf Pedersen, Wender Bredie, Torben Hansen, Niels Grarup","doi":"10.1016/j.tjnut.2025.06.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Taste liking, a complex trait, plays an important role in food choice and eating behavior, thereby influencing risk of diet-related diseases.</p><p><strong>Objectives: </strong>This study aimed to identify novel loci that could explain differences in liking of 5 basic tastes, fat sensation, and 2 oral sensations, represented by several food items.</p><p><strong>Methods: </strong>Liking scores were derived using a newly developed taste liking questionnaire (TasteLQ), validated in the Danish population. We conducted a genome-wide association study (GWAS) of liking of 6 modalities (sweet, salty, sour, bitter-astringency, umami, and pungency) and 9 factors representing modality subgroups among 6,437 Danish adults. As a secondary analysis, GWASs of 44 single food items from TasteLQ were also undertaken.</p><p><strong>Results: </strong>We identified 1 genome-wide significant variant, rs170518 (minor allele frequency = 0.16), on chromosome 5, associated with liking of an umami factor characterized by glutamate-rich food items [P = 3.7 × 10<sup>-8</sup>, beta = 0.14 standard deviation (SD) (standard error (SE)) = 0.03]. When analyzing individual food items, 4 single nucleotide polymorphisms (SNPs) within 1 locus, annotated to the bitter taste receptor gene, TAS2R38, were associated with liking of bitter-tasting rocket salad. Finally, our data confirmed some of the previously associated genomic variants with taste perception, food liking, and intake.</p><p><strong>Conclusions: </strong>Although our findings provide insight into loci involved in taste liking, they remain preliminary and warrant additional validation due to lack of replication in an independent population and limited number of genome-wide significant associations.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Genome-Wide Association Study of Taste Liking in the Danish Population.\",\"authors\":\"Sara Haydar, Camilla Cederbye Karlsson, Allan Linneberg, Line Lund Kårhus, Lars Ängquist, Oluf Pedersen, Wender Bredie, Torben Hansen, Niels Grarup\",\"doi\":\"10.1016/j.tjnut.2025.06.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Taste liking, a complex trait, plays an important role in food choice and eating behavior, thereby influencing risk of diet-related diseases.</p><p><strong>Objectives: </strong>This study aimed to identify novel loci that could explain differences in liking of 5 basic tastes, fat sensation, and 2 oral sensations, represented by several food items.</p><p><strong>Methods: </strong>Liking scores were derived using a newly developed taste liking questionnaire (TasteLQ), validated in the Danish population. We conducted a genome-wide association study (GWAS) of liking of 6 modalities (sweet, salty, sour, bitter-astringency, umami, and pungency) and 9 factors representing modality subgroups among 6,437 Danish adults. As a secondary analysis, GWASs of 44 single food items from TasteLQ were also undertaken.</p><p><strong>Results: </strong>We identified 1 genome-wide significant variant, rs170518 (minor allele frequency = 0.16), on chromosome 5, associated with liking of an umami factor characterized by glutamate-rich food items [P = 3.7 × 10<sup>-8</sup>, beta = 0.14 standard deviation (SD) (standard error (SE)) = 0.03]. When analyzing individual food items, 4 single nucleotide polymorphisms (SNPs) within 1 locus, annotated to the bitter taste receptor gene, TAS2R38, were associated with liking of bitter-tasting rocket salad. Finally, our data confirmed some of the previously associated genomic variants with taste perception, food liking, and intake.</p><p><strong>Conclusions: </strong>Although our findings provide insight into loci involved in taste liking, they remain preliminary and warrant additional validation due to lack of replication in an independent population and limited number of genome-wide significant associations.</p>\",\"PeriodicalId\":16620,\"journal\":{\"name\":\"Journal of Nutrition\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tjnut.2025.06.001\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tjnut.2025.06.001","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
A Genome-Wide Association Study of Taste Liking in the Danish Population.
Background: Taste liking, a complex trait, plays an important role in food choice and eating behavior, thereby influencing risk of diet-related diseases.
Objectives: This study aimed to identify novel loci that could explain differences in liking of 5 basic tastes, fat sensation, and 2 oral sensations, represented by several food items.
Methods: Liking scores were derived using a newly developed taste liking questionnaire (TasteLQ), validated in the Danish population. We conducted a genome-wide association study (GWAS) of liking of 6 modalities (sweet, salty, sour, bitter-astringency, umami, and pungency) and 9 factors representing modality subgroups among 6,437 Danish adults. As a secondary analysis, GWASs of 44 single food items from TasteLQ were also undertaken.
Results: We identified 1 genome-wide significant variant, rs170518 (minor allele frequency = 0.16), on chromosome 5, associated with liking of an umami factor characterized by glutamate-rich food items [P = 3.7 × 10-8, beta = 0.14 standard deviation (SD) (standard error (SE)) = 0.03]. When analyzing individual food items, 4 single nucleotide polymorphisms (SNPs) within 1 locus, annotated to the bitter taste receptor gene, TAS2R38, were associated with liking of bitter-tasting rocket salad. Finally, our data confirmed some of the previously associated genomic variants with taste perception, food liking, and intake.
Conclusions: Although our findings provide insight into loci involved in taste liking, they remain preliminary and warrant additional validation due to lack of replication in an independent population and limited number of genome-wide significant associations.
期刊介绍:
The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.