{"title":"新型人工晶状体材料的生物相容性评价。","authors":"Ayat Qassoom, Guy Kleinmann","doi":"10.1097/j.jcrs.0000000000001708","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the uveal and capsular biocompatibility of a new material for intraocular lens (IOL) fabrication, manufactured entirely from a crosslinked polyisobutylene (xPIB) polymer, in comparison to a commercial reference IOL in a rabbit model.</p><p><strong>Setting: </strong>Envigo CRS Israel Limited, Weizmann Science Park, Ness-Ziona, Israel.</p><p><strong>Design: </strong>Prospective, comparative, randomized animal study.</p><p><strong>Methods: </strong>Bilateral phacoemulsification was performed in 10 rabbits; 1 eye was implanted with the test IOL, the xPIB IOL, and the other eye was implanted with a reference IOL. Slit-lamp examinations were performed at postoperative weeks 1 and 6. The rabbits were euthanized at six weeks postoperatively, and the eyes were enucleated. After gross examination with the Miyake-Apple view, all eyes were sectioned and processed for histopathologic examination.</p><p><strong>Results: </strong>No difference was found in the uveal and capsular biocompatibility of the study and control IOLs in the biomicroscopy, Miyake-Apple posterior view, and histopathologic examination. A trend toward lower incidence and mean group severity of Soemmerring's ring was found in the test IOL group.</p><p><strong>Conclusions: </strong>The xPIB IOL was found non-inferior to the reference IOL. Both groups demonstrated the typical, expected ocular reactions of PCO and Soemmerring's ring after IOL implantation in rabbit eyes.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biocompatibility Evaluation of a New Material for Intraocular Lenses.\",\"authors\":\"Ayat Qassoom, Guy Kleinmann\",\"doi\":\"10.1097/j.jcrs.0000000000001708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the uveal and capsular biocompatibility of a new material for intraocular lens (IOL) fabrication, manufactured entirely from a crosslinked polyisobutylene (xPIB) polymer, in comparison to a commercial reference IOL in a rabbit model.</p><p><strong>Setting: </strong>Envigo CRS Israel Limited, Weizmann Science Park, Ness-Ziona, Israel.</p><p><strong>Design: </strong>Prospective, comparative, randomized animal study.</p><p><strong>Methods: </strong>Bilateral phacoemulsification was performed in 10 rabbits; 1 eye was implanted with the test IOL, the xPIB IOL, and the other eye was implanted with a reference IOL. Slit-lamp examinations were performed at postoperative weeks 1 and 6. The rabbits were euthanized at six weeks postoperatively, and the eyes were enucleated. After gross examination with the Miyake-Apple view, all eyes were sectioned and processed for histopathologic examination.</p><p><strong>Results: </strong>No difference was found in the uveal and capsular biocompatibility of the study and control IOLs in the biomicroscopy, Miyake-Apple posterior view, and histopathologic examination. A trend toward lower incidence and mean group severity of Soemmerring's ring was found in the test IOL group.</p><p><strong>Conclusions: </strong>The xPIB IOL was found non-inferior to the reference IOL. Both groups demonstrated the typical, expected ocular reactions of PCO and Soemmerring's ring after IOL implantation in rabbit eyes.</p>\",\"PeriodicalId\":15214,\"journal\":{\"name\":\"Journal of cataract and refractive surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cataract and refractive surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/j.jcrs.0000000000001708\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cataract and refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/j.jcrs.0000000000001708","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：评估一种完全由交联聚异丁烯（xPIB）聚合物制成的人工晶状体（IOL）的新材料的葡萄膜和荚膜的生物相容性，并在兔模型中与商业参考IOL进行比较。地点：Envigo CRS Israel Limited， Weizmann Science Park, Ness-Ziona, Israel。设计：前瞻性、比较、随机动物研究。方法：对10只兔进行双侧超声乳化术；1眼植入试验IOL和xPIB IOL，另一只眼植入参考IOL。术后第1周和第6周行裂隙灯检查。术后6周对兔实施安乐死，摘除眼球。经Miyake-Apple视图大体检查后，所有眼切片并进行组织病理学检查。结果：生物显微镜、Miyake-Apple后视图及组织病理学检查均未发现研究型和对照型人工晶状体的葡萄膜和荚膜生物相容性差异。试验人工晶状体组有较低发生率和组平均严重程度的趋势。结论：xPIB人工晶状体优于参考晶状体。两组均表现出兔眼人工晶状体植入术后的PCO和索默林氏环的典型、预期的眼部反应。
Biocompatibility Evaluation of a New Material for Intraocular Lenses.
Purpose: To evaluate the uveal and capsular biocompatibility of a new material for intraocular lens (IOL) fabrication, manufactured entirely from a crosslinked polyisobutylene (xPIB) polymer, in comparison to a commercial reference IOL in a rabbit model.
Setting: Envigo CRS Israel Limited, Weizmann Science Park, Ness-Ziona, Israel.
Methods: Bilateral phacoemulsification was performed in 10 rabbits; 1 eye was implanted with the test IOL, the xPIB IOL, and the other eye was implanted with a reference IOL. Slit-lamp examinations were performed at postoperative weeks 1 and 6. The rabbits were euthanized at six weeks postoperatively, and the eyes were enucleated. After gross examination with the Miyake-Apple view, all eyes were sectioned and processed for histopathologic examination.
Results: No difference was found in the uveal and capsular biocompatibility of the study and control IOLs in the biomicroscopy, Miyake-Apple posterior view, and histopathologic examination. A trend toward lower incidence and mean group severity of Soemmerring's ring was found in the test IOL group.
Conclusions: The xPIB IOL was found non-inferior to the reference IOL. Both groups demonstrated the typical, expected ocular reactions of PCO and Soemmerring's ring after IOL implantation in rabbit eyes.
期刊介绍：
The Journal of Cataract & Refractive Surgery (JCRS), a preeminent peer-reviewed monthly ophthalmology publication, is the official journal of the American Society of Cataract and Refractive Surgery (ASCRS) and the European Society of Cataract and Refractive Surgeons (ESCRS).
JCRS publishes high quality articles on all aspects of anterior segment surgery. In addition to original clinical studies, the journal features a consultation section, practical techniques, important cases, and reviews as well as basic science articles.
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