{"title":"神经精神症状和阿尔茨海默病严重程度。关注性别差异。","authors":"Antonina Luca, Maria Luca, Alessandro Serretti","doi":"10.1080/07317115.2025.2518093","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to investigate possible sex predictors in the severity of NPS in a large cohort of patients with AD and to assess the role of severity in sex-related differences in NPS.</p><p><strong>Methods: </strong>Four hundred and twenty-four participants (295 women, mean age 78.4 ± 8.3 years, mean disease duration 7.4 ± 8.5 years) were included with a diagnosis of AD according to NINCDS/ADRDA criteria. Clinical data and presence of NPS were collected from family interview, medical records, and patient interview and examination. Dementia severity was assessed using the Clinical Dementia Rating Scale (CDRS) extended version.</p><p><strong>Results: </strong>CDRS score was available for 407 participants (mean score 2.6 ± 1.1); 407 (22.1%) patients had CRDS = 1, 104 (25.5%) had CRDS = 2, 127 (31.2%) had CRDS = 3, 64 (15.7%) had CDRS = 4 and 22 (15.4%) had CDRS = 5. Apathy (85.7%), agitation or restlessness (75.1%) and paranoia (59.4%) were the most common NPS. Higher CDRS scores were associated with several neuropsychiatric features, including apathy, wandering and physical aggression. In the sex-stratified analysis, NPS were associated with more severe AD only in men.</p><p><strong>Conclusions: </strong>Our findings suggest relevant sex differences in NPS with increasing severity.</p><p><strong>Clinical implications: </strong>A timely and targeted behavioral management could improve treatment outcome.</p>","PeriodicalId":10376,"journal":{"name":"Clinical Gerontologist","volume":" ","pages":"1-7"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuropsychiatric Symptoms and Alzheimer's Disease Severity. A Focus on Sex-Differences.\",\"authors\":\"Antonina Luca, Maria Luca, Alessandro Serretti\",\"doi\":\"10.1080/07317115.2025.2518093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The aim of the present study was to investigate possible sex predictors in the severity of NPS in a large cohort of patients with AD and to assess the role of severity in sex-related differences in NPS.</p><p><strong>Methods: </strong>Four hundred and twenty-four participants (295 women, mean age 78.4 ± 8.3 years, mean disease duration 7.4 ± 8.5 years) were included with a diagnosis of AD according to NINCDS/ADRDA criteria. Clinical data and presence of NPS were collected from family interview, medical records, and patient interview and examination. Dementia severity was assessed using the Clinical Dementia Rating Scale (CDRS) extended version.</p><p><strong>Results: </strong>CDRS score was available for 407 participants (mean score 2.6 ± 1.1); 407 (22.1%) patients had CRDS = 1, 104 (25.5%) had CRDS = 2, 127 (31.2%) had CRDS = 3, 64 (15.7%) had CDRS = 4 and 22 (15.4%) had CDRS = 5. Apathy (85.7%), agitation or restlessness (75.1%) and paranoia (59.4%) were the most common NPS. Higher CDRS scores were associated with several neuropsychiatric features, including apathy, wandering and physical aggression. In the sex-stratified analysis, NPS were associated with more severe AD only in men.</p><p><strong>Conclusions: </strong>Our findings suggest relevant sex differences in NPS with increasing severity.</p><p><strong>Clinical implications: </strong>A timely and targeted behavioral management could improve treatment outcome.</p>\",\"PeriodicalId\":10376,\"journal\":{\"name\":\"Clinical Gerontologist\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Gerontologist\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/07317115.2025.2518093\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Gerontologist","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07317115.2025.2518093","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Neuropsychiatric Symptoms and Alzheimer's Disease Severity. A Focus on Sex-Differences.
Objectives: The aim of the present study was to investigate possible sex predictors in the severity of NPS in a large cohort of patients with AD and to assess the role of severity in sex-related differences in NPS.
Methods: Four hundred and twenty-four participants (295 women, mean age 78.4 ± 8.3 years, mean disease duration 7.4 ± 8.5 years) were included with a diagnosis of AD according to NINCDS/ADRDA criteria. Clinical data and presence of NPS were collected from family interview, medical records, and patient interview and examination. Dementia severity was assessed using the Clinical Dementia Rating Scale (CDRS) extended version.
Results: CDRS score was available for 407 participants (mean score 2.6 ± 1.1); 407 (22.1%) patients had CRDS = 1, 104 (25.5%) had CRDS = 2, 127 (31.2%) had CRDS = 3, 64 (15.7%) had CDRS = 4 and 22 (15.4%) had CDRS = 5. Apathy (85.7%), agitation or restlessness (75.1%) and paranoia (59.4%) were the most common NPS. Higher CDRS scores were associated with several neuropsychiatric features, including apathy, wandering and physical aggression. In the sex-stratified analysis, NPS were associated with more severe AD only in men.
Conclusions: Our findings suggest relevant sex differences in NPS with increasing severity.
Clinical implications: A timely and targeted behavioral management could improve treatment outcome.
期刊介绍：
Clinical Gerontologist presents original research, reviews, and clinical comments relevant to the needs of behavioral health professionals and all practitioners who work with older adults. Published in cooperation with Psychologists in Long Term Care, the journal is designed for psychologists, physicians, nurses, social workers, counselors (family, pastoral, and vocational), and other health professionals who address behavioral health concerns found in later life, including:
-adjustments to changing roles-
issues related to diversity and aging-
family caregiving-
spirituality-
cognitive and psychosocial assessment-
depression, anxiety, and PTSD-
Alzheimer’s disease and other neurocognitive disorders-
long term care-
behavioral medicine in aging-
rehabilitation and education for older adults.
Each issue provides insightful articles on current topics. Submissions are peer reviewed by content experts and selected for both scholarship and relevance to the practitioner to ensure that the articles are among the best in the field. Authors report original research and conceptual reviews. A unique column in Clinical Gerontologist is “Clinical Comments." This section features brief observations and specific suggestions from practitioners which avoid elaborate research designs or long reference lists. This section is a unique opportunity for you to learn about the valuable clinical work of your peers in a short, concise format.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
