Weijia Xu, Mingda Yang, Jihong Wang, Jie Li, Menghua Xiong, Ziyang Cao, Xianzhu Yang
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Artificial Cytotoxic T Lymphocytes Selectively Eliminate Tumor Cells for Effective Cancer Therapy.
The highly selective ability of cytotoxic T lymphocytes (CTLs) to eliminate tumor cells has inspired the development of artificial nanomedicine for effective cancer therapy. Here, an artificial CTL (aCTL) that selectively recognizes and kills cancer cells is developed. The membrane target-binding moiety, membrane-perforating peptides, and therapeutic prodrugs are integrated into the aCTL through supramolecular interactions. Consequently, the prepared aCTL selectively binds cancer cells and perforates the surrounding membrane. Subsequently, the conjugated prodrug is cleaved and released by the overexpressed membrane transpeptidase, allowing entry into tumor cells through the perforated holes. Finally, the aCTL significantly suppresses the growth of HepG2 hepatocellular carcinoma, B16-F10 melanomas, and patient-derived xenograft (PDX) breast cancer models.
期刊介绍：
Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including:
- Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale
- Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies
- Modeling and simulation of synthetic, assembly, and interaction processes
- Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance
- Applications of nanoscale materials in living and environmental systems
Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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