腺样囊性癌的分子进展：遗传学和表观遗传学的见解

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-06-06 DOI:10.1016/j.archoralbio.2025.106323

Luciana Oliveira Almeida , Kevin Luiz Lopes-Delphino , Isabel Schausltz Pereira Faustino , Lara Maria Alencar Ramos Innocentini , Luiz Carlos Conti de Freitas , Pedro Polastri Lima Peixoto , Ana Carolina Fragoso Motta , Lucas Dias de Oliveira , Rogério Moraes Castilho , Katiuchia Uzzun Sales

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引用次数: 0

摘要

目的综述腺样囊性癌的遗传和表观遗传改变，探讨其预后、治疗、复发和多学科管理方面的挑战。通过检索PubMed、Scopus、Web of Science、EMBASE、LILACS和谷歌Scholar数据库，使用相关关键词，并通过人工检索对期刊文章的参考文献列表进行验证，进行叙述综述。结果MYB-NFIB融合是腺样囊性癌的一个标志性遗传特征，影响肿瘤行为和对凋亡的抵抗。PI3K/AKT和NOTCH通路的改变有助于腺样囊性癌的侵袭性特征，如神经周围的侵袭和转移。表观遗传修饰，包括DNA甲基化和组蛋白改变，也与肿瘤进展和预后不良有关。蛋白酶如MMP-9和组织蛋白酶D和B与侵袭性疾病和预后相关。尽管腺样囊性癌的罕见性挑战临床试验，这些分子标记仍然是有价值的治疗靶点。结论腺样囊性癌的分子复杂性强调了针对其特定遗传和表观遗传景观的靶向治疗的必要性。未来的研究应优先考虑分子靶向治疗和表观遗传干预在改善腺样囊性癌预后中的作用的临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Molecular advances in adenoid cystic carcinoma: Genetic and epigenetic insights

Objective

This review aims to provide an overview of genetic and epigenetic alterations in adenoid cystic carcinoma, addressing challenges in prognosis, treatment, recurrence, and multidisciplinary management.

Design

A narrative review was conducted through searches in the PubMed, Scopus, Web of Science, EMBASE, LILACS and Google Scholar databases, using relevant keywords and including the verification of reference lists from journal articles through manual searching.

Results

The MYB-NFIB fusion emerged as a hallmark genetic feature of adenoid cystic carcinoma, influencing tumor behavior and resistance to apoptosis. Alterations in the PI3K/AKT and NOTCH pathways contributed to adenoid cystic carcinoma’s aggressive traits, such as perineural invasion and metastasis. Epigenetic modifications, including DNA methylation and histone changes, were also linked to tumor progression and poor prognosis. Proteases such as MMP-9 and cathepsins D and B are associated with aggressive disease and prognosis. Although adenoid cystic carcinoma's rarity challenges clinical trials, these molecular markers remain valuable therapeutic targets.

Conclusion

The molecular complexity of adenoid cystic carcinoma underscores the need for targeted therapies that address its specific genetic and epigenetic landscape. Future research should prioritize clinical trials focusing on molecularly targeted treatments and epigenetic interventions' role in improving adenoid cystic carcinoma outcomes.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry