细胞器结构对卵母细胞发育潜能的影响

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-11 DOI:10.1016/j.ceb.2025.102556

Elvira Nikalayevich, Noemi Zollo, Marie-Hélène Verlhac

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引用次数: 0

摘要

卵母细胞是雌性配子，专门储存受精后胚胎发育所必需的母体rna、蛋白质、脂质和代谢物，有时在人类中存在数十年。为了支持这种延长的寿命，卵母细胞进化出了组织专门细胞器的机制。本综述重点介绍了卵母细胞如何随时间调节mRNA和蛋白质的积累、储存和降解的最新发现。此外，我们还探讨了细胞质活性和重塑的研究进展，特别是皮层机械特性在微调细胞器分布和功能以确保卵母细胞发育中的作用。

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Impact of organelle architecture on oocyte developmental potential

Oocytes are female gametes specialized in storing maternal RNAs, proteins, lipids, and metabolites essential for embryonic development after fertilization, sometimes for decades in humans. To support this extended lifespan, oocytes have evolved mechanisms to organize specialized organelles. This review highlights recent discoveries on how oocytes regulate mRNA and protein accumulation, storage, and degradation over time. Additionally, we explore advances in understanding cytoplasmic activity and remodeling, particularly the role of cortex mechanical properties in fine-tuning organelle distribution and function to ensure proper oocyte development.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.