Triterpenoids from Garcinia oligantha and their affinity with vascular endothelial growth factor receptor-2

Garcinia oligantha Merr., a traditional herb, is widely used in folk medicines for the treatment of various ailments. To explore its potential medicinal value, a chemical investigation on G. oligantha was conducted, leading to the isolation and identification of five triterpenoids, including two new lupane-type triterpenes and three known oleanane-type triterpenes. The structures of these compounds were precisely elucidated using spectroscopic techniques, such as NMR, HRESIMS, and CD. To assess their potential bioactivity, affinity screening was performed, which revealed that compounds 3−5 exhibited significant affinity for vascular endothelial growth factor receptor 2 (VEGFR-2), an important target for anti-cancer drug development. Further molecular docking studies elucidated the binding modes of these compounds with VEGFR-2. This study not only enriches the understanding of the chemical constituents of G. oligantha but also provides potential bioactive molecules for the development of novel anti-cancer drugs.