富硒螺旋藻在减轻链脲佐菌素诱导的认知障碍中的神经营养潜力：阿尔茨海默病大鼠模型中氧化应激和乙酰胆碱活性的调节

IF 2.7 3区生物学 Q2 PLANT SCIENCES

South African Journal of Botany Pub Date : 2025-06-10 DOI:10.1016/j.sajb.2025.05.039

Fatemeh zeini hamzekolaei , Akbar Hajizadeh Moghaddam , Mahbobe Ghanbarzadeh , Ehsan Nazifi , Sedigheh Khanjani Jelodar

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引用次数: 0

摘要

本研究旨在探讨含富硒螺旋藻（Se-SP）的神经营养制剂对脑室注射链脲佐菌素（ICV-STZ）诱导的认知和行为障碍、胆碱能缺陷、硒缺乏和氧化应激的影响。DPPH法测定Se-SP的抗氧化能力，ICP-MS法测定Se-SP的硒含量。50只雄性大鼠被随机分为五组。注射ICV-STZ后开始口服神经营养制剂（50 mg/kg），持续21天。评估硒水平、胆碱能功能、氧化应激标志物和认知能力。结果表明，硒- sp处理通过抑制乙酰胆碱酯酶活性来防止乙酰胆碱耗竭，并显著提高行为测试成绩。硒- sp提高了硒酶谷胱甘肽过氧化物酶的活性，对脑硒缺乏具有保护作用。它还通过增强抗氧化防御，有效地减少了icv - stz诱导的脂质过氧化。这些发现表明Se-SP作为一种有机抗氧化剂补充剂，有望减轻氧化应激和胆碱能功能障碍，从而减轻认知障碍

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Neuro-nutraceutical potential of selenium-enriched spirulina platensis in alleviating streptozotocin-induced cognitive impairment: Modulation of oxidative stress and acetylcholine activity in a rat model of Alzheimer's disease

This study aimed to investigate the effects of a neuro-nutraceutical formulation comprising selenium-enriched Spirulina platensis (Se-SP) on cognitive and behavioral impairments, cholinergic deficits, selenium deficiency, and oxidative stress induced by intracerebroventricular injection of streptozotocin (ICV-STZ). The antioxidant capacity of Se-SP was confirmed through DPPH assay, and its selenium content was quantified using ICP-MS analysis. Fifty male rats were randomly assigned to five groups. Oral administration of the neuro-nutraceutical formulation (50 mg/kg) began after ICV-STZ injection and continued for 21 days. Selenium levels, cholinergic function, oxidative stress markers, and cognitive performance were evaluated.

The results demonstrated that Se-SP treatment prevented acetylcholine depletion by inhibiting acetylcholinesterase activity and significantly improved behavioral test performance. Furthermore, Se-SP enhanced the activity of the selenoenzyme glutathione peroxidase, protecting against brain selenium depletion. It also effectively reduced ICV-STZ-induced lipid peroxidation by boosting antioxidant defenses. These findings suggest that Se-SP, as an organic antioxidant supplement, holds promise for alleviating oxidative stress and cholinergic dysfunction, thereby mitigating cognitive impairment

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来源期刊

South African Journal of Botany 生物-植物科学

CiteScore

5.20

自引率

9.70%

发文量

709

审稿时长

61 days

期刊介绍： The South African Journal of Botany publishes original papers that deal with the classification, biodiversity, morphology, physiology, molecular biology, ecology, biotechnology, ethnobotany and other botanically related aspects of species that are of importance to southern Africa. Manuscripts dealing with significant new findings on other species of the world and general botanical principles will also be considered and are encouraged.