进化医学的作用：镰状血红蛋白促进肿瘤进展

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-06-10 DOI:10.1016/j.immuni.2025.05.012

Miguel P. Soares

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引用次数: 0

摘要

进化医学整合了进化生物学的原理来理解和治疗人类疾病。作为一个经典的例子，镰状血红蛋白突变的阳性选择在杂合子个体中具有抵抗疟疾的生存优势，但在纯合子中导致镰状细胞病。在这一期的《免疫》杂志上，赵子龙等人报道了镰状血红蛋白可能存在的另一种进化权衡：抗肿瘤免疫功能受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evolutionary medicine in action: Sickle hemoglobin fuels tumor progression

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Evolutionary medicine in action: Sickle hemoglobin fuels tumor progression

Evolutionary medicine integrates principles of evolutionary biology to understand and treat human diseases. As a classical example, positive selection of the sickle hemoglobin mutation, which confers a survival advantage against malaria in heterozygous individuals, causes sickle cell disease in homozygotes. In this issue of Immunity, Zilong Zhao et al. report a possible additional evolutionary trade-off associated with sickle hemoglobin: compromised anti-tumor immunity.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.