甘氨酸衍生物原位生成NHPl酯的可见光驱动C(sp³)-H脱羧烷基化反应

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Lan Yang, Yi-Yang Tang, Si-Yu Gao and Peng-Lin Zhang
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引用次数: 0

摘要

通过原位形成NHPl酯的甘氨酸衍生物的可见光驱动脱羧C(sp³)-H烷基化。采用Xantphos/ICH₂CH₂I体系作为双活化剂和催化剂,避免了昂贵的光催化剂和过渡金属。在温和的条件下,建立了一个通用的平台,从容易获得的具有高官能团耐受性的烷基羧酸合成非天然氨基酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Visible-light-driven decarboxylative C(sp3)–H alkylation of glycine derivatives via in situ formation of NHPI esters†

Visible-light-driven decarboxylative C(sp3)–H alkylation of glycine derivatives via in situ formation of NHPI esters†

A visible-light-driven decarboxylative C(sp3)–H alkylation of glycine derivatives via in situ formation of NHPI esters is reported. The use of the Xantphos/ICH2CH2I system as a dual activator and a catalyst eliminates the need for expensive photocatalysts and transition metals. Under mild conditions, a versatile platform is established for synthesizing unnatural amino acids from readily available alkyl carboxylic acids with high functional group tolerance.

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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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