Iván A Escalante-Pérez, Ana A Alviares, Óscar D Omaña-Ávila, Fhabián S Carrión-Nessi, Daniela L Mendoza-Millán, Grecia de J Erimee-Vieira, Juan M Contreras-Rengifo, Vanessa C Sande-Mujica, Mariana de J de Marchis-Vento, Karim J Gebran-Chedid, Mario A Dubuc-Ponte, Daniela I Castro-Betancourt, Vittoria F Fuentes-Fiore, Rachell A Molina-Mendoza, Alejandro M Loreto-Rodrigues, Juan C Gomes-González, Luciano Mauriello, Eyleen Moronta, Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, David A Forero-Peña
{"title":"委内瑞拉瓜纳雷查加斯病的流行、知识、态度和做法：一项横断面研究。","authors":"Iván A Escalante-Pérez, Ana A Alviares, Óscar D Omaña-Ávila, Fhabián S Carrión-Nessi, Daniela L Mendoza-Millán, Grecia de J Erimee-Vieira, Juan M Contreras-Rengifo, Vanessa C Sande-Mujica, Mariana de J de Marchis-Vento, Karim J Gebran-Chedid, Mario A Dubuc-Ponte, Daniela I Castro-Betancourt, Vittoria F Fuentes-Fiore, Rachell A Molina-Mendoza, Alejandro M Loreto-Rodrigues, Juan C Gomes-González, Luciano Mauriello, Eyleen Moronta, Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, David A Forero-Peña","doi":"10.1186/s13071-025-06846-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chagas disease (CD) is endemic in 21 Latin American countries, placing approximately 75 million people at risk of infection. In Venezuela, CD has been recognized since 1919, with seroprevalence estimates reaching up to 45% between 1958 and 1968. However, current data on the epidemiology of CD in Venezuela are limited.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in September 2023 in Guanare municipality, located in northwestern Portuguesa state. Seroprevalence was determined by detecting anti-Trypanosoma cruzi IgG antibodies and assessing specific-IgG avidity enzyme-linked immunosorbent assay (ELISA). Additionally, we evaluated knowledge, attitudes, and practices (KAPs) regarding CD in the region.</p><p><strong>Results: </strong>A total of 388 participants were enrolled, with a mean age of 29 (standard deviation [SD] = 21) years; 67% (n = 260) were female. Seven individuals, aged between 62 and 75 years, tested positive for T. cruzi, yielding an estimated seroprevalence of 2%. Among these ELISA-confirmed cases, the majority were men (71%, n = 5) with a mean age of 67 (SD = 5) years. Their occupations included construction work (42%, n = 3), farming (29%, n = 2), and housekeeping (29%, n = 2). In the KAP survey, 28% of respondents reported having a family member with CD, and 39% recalled observing the insect vector in their homes. Notably, 83% were aware that CD is transmitted by an insect vector. Although over 70% expressed positive attitudes toward educational initiatives and indicated willingness to collaborate with health services for prompt diagnosis and vector elimination, more than 80% reported inadequate vector control practices.</p><p><strong>Conclusions: </strong>The seroprevalence of CD in the Guanare population was 2%, with all positive cases occurring in individuals over 60 years of age, suggesting an absence of active transmission in the area. While community knowledge and attitudes regarding CD were generally favorable, vector control practices were suboptimal. Future studies employing probabilistic sampling across various regions of the state are needed to further elucidate the epidemiology of CD in Venezuela.</p>","PeriodicalId":19793,"journal":{"name":"Parasites & Vectors","volume":"18 1","pages":"215"},"PeriodicalIF":3.0000,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147284/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence, knowledge, attitudes, and practices regarding Chagas disease in Guanare, Venezuela: a cross-sectional study.\",\"authors\":\"Iván A Escalante-Pérez, Ana A Alviares, Óscar D Omaña-Ávila, Fhabián S Carrión-Nessi, Daniela L Mendoza-Millán, Grecia de J Erimee-Vieira, Juan M Contreras-Rengifo, Vanessa C Sande-Mujica, Mariana de J de Marchis-Vento, Karim J Gebran-Chedid, Mario A Dubuc-Ponte, Daniela I Castro-Betancourt, Vittoria F Fuentes-Fiore, Rachell A Molina-Mendoza, Alejandro M Loreto-Rodrigues, Juan C Gomes-González, Luciano Mauriello, Eyleen Moronta, Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, David A Forero-Peña\",\"doi\":\"10.1186/s13071-025-06846-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chagas disease (CD) is endemic in 21 Latin American countries, placing approximately 75 million people at risk of infection. In Venezuela, CD has been recognized since 1919, with seroprevalence estimates reaching up to 45% between 1958 and 1968. However, current data on the epidemiology of CD in Venezuela are limited.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in September 2023 in Guanare municipality, located in northwestern Portuguesa state. Seroprevalence was determined by detecting anti-Trypanosoma cruzi IgG antibodies and assessing specific-IgG avidity enzyme-linked immunosorbent assay (ELISA). Additionally, we evaluated knowledge, attitudes, and practices (KAPs) regarding CD in the region.</p><p><strong>Results: </strong>A total of 388 participants were enrolled, with a mean age of 29 (standard deviation [SD] = 21) years; 67% (n = 260) were female. Seven individuals, aged between 62 and 75 years, tested positive for T. cruzi, yielding an estimated seroprevalence of 2%. Among these ELISA-confirmed cases, the majority were men (71%, n = 5) with a mean age of 67 (SD = 5) years. Their occupations included construction work (42%, n = 3), farming (29%, n = 2), and housekeeping (29%, n = 2). In the KAP survey, 28% of respondents reported having a family member with CD, and 39% recalled observing the insect vector in their homes. Notably, 83% were aware that CD is transmitted by an insect vector. Although over 70% expressed positive attitudes toward educational initiatives and indicated willingness to collaborate with health services for prompt diagnosis and vector elimination, more than 80% reported inadequate vector control practices.</p><p><strong>Conclusions: </strong>The seroprevalence of CD in the Guanare population was 2%, with all positive cases occurring in individuals over 60 years of age, suggesting an absence of active transmission in the area. While community knowledge and attitudes regarding CD were generally favorable, vector control practices were suboptimal. Future studies employing probabilistic sampling across various regions of the state are needed to further elucidate the epidemiology of CD in Venezuela.</p>\",\"PeriodicalId\":19793,\"journal\":{\"name\":\"Parasites & Vectors\",\"volume\":\"18 1\",\"pages\":\"215\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147284/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasites & Vectors\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13071-025-06846-4\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasites & Vectors","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13071-025-06846-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Prevalence, knowledge, attitudes, and practices regarding Chagas disease in Guanare, Venezuela: a cross-sectional study.
Background: Chagas disease (CD) is endemic in 21 Latin American countries, placing approximately 75 million people at risk of infection. In Venezuela, CD has been recognized since 1919, with seroprevalence estimates reaching up to 45% between 1958 and 1968. However, current data on the epidemiology of CD in Venezuela are limited.
Methods: We conducted a cross-sectional study in September 2023 in Guanare municipality, located in northwestern Portuguesa state. Seroprevalence was determined by detecting anti-Trypanosoma cruzi IgG antibodies and assessing specific-IgG avidity enzyme-linked immunosorbent assay (ELISA). Additionally, we evaluated knowledge, attitudes, and practices (KAPs) regarding CD in the region.
Results: A total of 388 participants were enrolled, with a mean age of 29 (standard deviation [SD] = 21) years; 67% (n = 260) were female. Seven individuals, aged between 62 and 75 years, tested positive for T. cruzi, yielding an estimated seroprevalence of 2%. Among these ELISA-confirmed cases, the majority were men (71%, n = 5) with a mean age of 67 (SD = 5) years. Their occupations included construction work (42%, n = 3), farming (29%, n = 2), and housekeeping (29%, n = 2). In the KAP survey, 28% of respondents reported having a family member with CD, and 39% recalled observing the insect vector in their homes. Notably, 83% were aware that CD is transmitted by an insect vector. Although over 70% expressed positive attitudes toward educational initiatives and indicated willingness to collaborate with health services for prompt diagnosis and vector elimination, more than 80% reported inadequate vector control practices.
Conclusions: The seroprevalence of CD in the Guanare population was 2%, with all positive cases occurring in individuals over 60 years of age, suggesting an absence of active transmission in the area. While community knowledge and attitudes regarding CD were generally favorable, vector control practices were suboptimal. Future studies employing probabilistic sampling across various regions of the state are needed to further elucidate the epidemiology of CD in Venezuela.
期刊介绍：
Parasites & Vectors is an open access, peer-reviewed online journal dealing with the biology of parasites, parasitic diseases, intermediate hosts, vectors and vector-borne pathogens. Manuscripts published in this journal will be available to all worldwide, with no barriers to access, immediately following acceptance. However, authors retain the copyright of their material and may use it, or distribute it, as they wish.
Manuscripts on all aspects of the basic and applied biology of parasites, intermediate hosts, vectors and vector-borne pathogens will be considered. In addition to the traditional and well-established areas of science in these fields, we also aim to provide a vehicle for publication of the rapidly developing resources and technology in parasite, intermediate host and vector genomics and their impacts on biological research. We are able to publish large datasets and extensive results, frequently associated with genomic and post-genomic technologies, which are not readily accommodated in traditional journals. Manuscripts addressing broader issues, for example economics, social sciences and global climate change in relation to parasites, vectors and disease control, are also welcomed.
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