{"title":"一种新的细胞毒性二苯乙烯。例钩)。斯坦。","authors":"Nonthalert Lertnitikul, Cherdsak Boonyong, Rutt Suttisri","doi":"10.1080/14786419.2025.2514732","DOIUrl":null,"url":null,"abstract":"<p><p>A new <i>trans-</i>stilbene, (<i>E</i>)-2,4-<i>bis</i>(4-hydroxybenzyl)-3,5-dihydroxystilbene (<b>1</b>), and ten known compounds including stilbenoids (<b>2</b>, <b>7</b>, <b>8</b>, <b>10</b>), coumaric acid ester (<b>3</b>), flavonoids (<b>4</b>-<b>6</b>), aromatic aldehyde (<b>9</b>) and triterpenoid glycoside (<b>11</b>) were isolated from the leaves and roots of the lady slipper's orchid <i>Paphiopedilum hirsutissimum</i> (Lindl. ex Hook.) Stein. The structures of these chemical constituents were determined based on their spectroscopic data and comparison with literature. <i>In vitro</i> cytotoxicity of all isolated compounds towards human hepatic cancer (HepG2) cell line was examined by MTT assay. Izalpinin (<b>6</b>) was potently cytotoxic to the cancer cells, with an IC<sub>50</sub> value of 4.62 ± 1.50 μM. Stilbenoids <b>2</b>, <b>7</b> and <b>8</b> also exhibited notable activity in the range of 6.31-6.68 μM. All compounds, except the new stilbene <b>1</b>, were non-toxic to normal fibroblast (OUMS-36) cell line.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A new cytotoxic stilbene from <i>Paphiopedilum hirsutissimum</i> (Lindl. ex Hook.) Stein.\",\"authors\":\"Nonthalert Lertnitikul, Cherdsak Boonyong, Rutt Suttisri\",\"doi\":\"10.1080/14786419.2025.2514732\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A new <i>trans-</i>stilbene, (<i>E</i>)-2,4-<i>bis</i>(4-hydroxybenzyl)-3,5-dihydroxystilbene (<b>1</b>), and ten known compounds including stilbenoids (<b>2</b>, <b>7</b>, <b>8</b>, <b>10</b>), coumaric acid ester (<b>3</b>), flavonoids (<b>4</b>-<b>6</b>), aromatic aldehyde (<b>9</b>) and triterpenoid glycoside (<b>11</b>) were isolated from the leaves and roots of the lady slipper's orchid <i>Paphiopedilum hirsutissimum</i> (Lindl. ex Hook.) Stein. The structures of these chemical constituents were determined based on their spectroscopic data and comparison with literature. <i>In vitro</i> cytotoxicity of all isolated compounds towards human hepatic cancer (HepG2) cell line was examined by MTT assay. Izalpinin (<b>6</b>) was potently cytotoxic to the cancer cells, with an IC<sub>50</sub> value of 4.62 ± 1.50 μM. Stilbenoids <b>2</b>, <b>7</b> and <b>8</b> also exhibited notable activity in the range of 6.31-6.68 μM. All compounds, except the new stilbene <b>1</b>, were non-toxic to normal fibroblast (OUMS-36) cell line.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2514732\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2514732","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
A new cytotoxic stilbene from Paphiopedilum hirsutissimum (Lindl. ex Hook.) Stein.
A new trans-stilbene, (E)-2,4-bis(4-hydroxybenzyl)-3,5-dihydroxystilbene (1), and ten known compounds including stilbenoids (2, 7, 8, 10), coumaric acid ester (3), flavonoids (4-6), aromatic aldehyde (9) and triterpenoid glycoside (11) were isolated from the leaves and roots of the lady slipper's orchid Paphiopedilum hirsutissimum (Lindl. ex Hook.) Stein. The structures of these chemical constituents were determined based on their spectroscopic data and comparison with literature. In vitro cytotoxicity of all isolated compounds towards human hepatic cancer (HepG2) cell line was examined by MTT assay. Izalpinin (6) was potently cytotoxic to the cancer cells, with an IC50 value of 4.62 ± 1.50 μM. Stilbenoids 2, 7 and 8 also exhibited notable activity in the range of 6.31-6.68 μM. All compounds, except the new stilbene 1, were non-toxic to normal fibroblast (OUMS-36) cell line.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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