儿童急性淋巴细胞白血病患者天冬酰胺酶诱导的胰腺炎后外分泌胰腺功能不全：一个病例系列。

IF 0.8 4区医学 Q4 HEMATOLOGY

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI:10.1097/MPH.0000000000003058

Rachel Hill, Lindsey Thomas, David Farbo, Kenneth Heym

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引用次数: 0

摘要

天冬酰胺酶对儿童急性淋巴细胞白血病（ALL）的治疗至关重要，但它可能引起许多不良反应，包括天冬酰胺酶相关性胰腺炎（AAP）。外分泌胰腺功能不全（EPI）已报道胰腺炎后，但尚未报道在儿童白血病设置。如果未确诊，EPI可导致营养恶化。本文描述了3例严重的坏死性AAP，随后出现持续时间不等的EPI。本病例系列的目的是记录这些发现，并提高对这些疾病之间关联的认识，以便在必要时及时识别和干预。

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Exocrine Pancreatic Insufficiency Following Asparaginase-induced Pancreatitis in Pediatric Acute Lymphoblastic Leukemia Patients: A Case Series.

Asparaginase is vital for the treatment of pediatric acute lymphoblastic leukemia (ALL), but it can cause numerous adverse effects, including asparaginase-associated pancreatitis (AAP). Exocrine pancreatic insufficiency (EPI) has been reported following pancreatitis but has not yet been reported in the setting of pediatric leukemia. If undiagnosed, EPI can lead to nutritional deterioration. This series describes 3 cases of severe, necrotizing AAP followed by EPI of variable duration. The purpose of this case series is to document these findings and increase awareness about the association between these conditions to facilitate timely identification and intervention, when warranted.

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来源期刊

Journal of Pediatric Hematology/Oncology 医学-小儿科

CiteScore

1.90

自引率

8.30%

发文量

415

审稿时长

2.5 months

期刊介绍： Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.