microRNA的文献计量学分析:对其在急性冠脉综合征中的作用的综合评价。

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S525150
Yuqian Gao, Tianli Li, Xiaohong Mu, Xiaoxia Ren, Jing Wang, Jiasai Fan, Haiyan Zhu, Xian Wang
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引用次数: 0

摘要

目的:本研究采用文献计量学分析来绘制与急性冠脉综合征(ACS)相关的microRNA (miRNA)研究的演变,识别新趋势,并评估关键研究主题。通过分析全球出版物,我们旨在突出miRNA在ACS诊断和治疗中的应用热点和翻译方向。材料和方法:检索Web of Science Core Collection中2007 - 2023年间发表的关于miRNA和ACS的文章。使用CiteSpace和VOSviewer分析了1244项符合条件的研究的数据,以评估国家、机构、作者、期刊和关键词的贡献。可视化工具映射了协作网络、共同引用模式和关键字趋势。结果:中国发表了60%的论文,其次是美国(12.86%)。哈尔滨医科大学是最具生产力的机构,而Thum Thomas则成为领先的研究人员。重点研究领域包括ACS诊断的miRNA生物标志物、缺血再灌注损伤的治疗靶点、心脏修复中的细胞外囊泡、细胞凋亡、自噬和炎症的机制研究。新兴前沿包括ami后心室重构、氧化应激和基于mirna的策略的临床翻译。结论:本研究首次提供了ACS中miRNA研究的综合文献计量学综述,揭示了持续增长和跨学科潜力。研究结果强调了中国在产出方面的主导地位,以及加强国际合作以弥合基础研究和临床应用之间差距的必要性。优先考虑细胞外囊泡介导的治疗,优化miRNA传递系统,并在多中心试验中验证生物标志物对未来的进展至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bibliometric Analysis of microRNA: A Comprehensive Evaluation of Its Contribution to Acute Coronary Syndromes.

Objective: This study employs bibliometric analysis to map the evolution, identify emerging trends, and evaluate key research themes in microRNA (miRNA) research related to Acute Coronary Syndromes (ACS). By analyzing global publications, we aim to highlight hotspots and translational directions for advancing miRNA applications in ACS diagnosis and therapy.

Materials and methods: Articles on miRNA and ACS published between 2007 and 2023 were retrieved from the Web of Science Core Collection. Data from 1,244 eligible studies were analyzed using CiteSpace and VOSviewer to assess contributions by countries, institutions, authors, journals, and keywords. Visualization tools mapped collaboration networks, co-citation patterns, and keyword trends.

Results: China contributed 60% of publications, followed by the United States (12.86%). Harbin Medical University was the most productive institution, while Thum Thomas emerged as the leading researcher. Key research areas included miRNA biomarkers for ACS diagnosis, therapeutic targets for ischemia-reperfusion injury, extracellular vesicles in cardiac repair, and mechanistic studies on apoptosis, autophagy, and inflammation. Emerging frontiers encompassed ventricular remodeling post-AMI, oxidative stress, and clinical translation of miRNA-based strategies.

Conclusion: This study provides the first comprehensive bibliometric overview of miRNA research in ACS, revealing sustained growth and interdisciplinary potential. Findings underscore China's dominance in output and the need for enhanced international collaboration to bridge gaps between basic research and clinical applications. Prioritizing extracellular vesicle-mediated therapies, optimizing miRNA delivery systems, and validating biomarkers in multicenter trials are critical for future advancements.

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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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