Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's disease.

The study of pathophysiology of Parkinson´s disease (PD) has been traditionally performed with functional magnetic resonance imaging (fMRI), however only a few studies have been set in longitudinal cohorts. In the present literature review, we aim to summarize the most recent progress in functional fMRI studies in prospective cohorts and more specifically in combination with other biomarkers, in order to track the disease progression of PD. This review focusses in the potential application of the multimodal longitudinal functional approaches based in the current evidence for the purpose to understand disease progression and monitoring future therapeutic interventions.